In the mammalian brain, a major regulatory peptide is vasoactive intestinal peptide (VIP).
This 28 amino acid peptide, originally isolated from the porcine duodenum, was later found …

Carcinoid tumors are the most commonly occurring gut endocrine tumors. The incidence of
these tumors is estimated to be approximately 1.5 cases per 100,000 of the general …

Ten patients with metastatic pancreatic endocrine tumours were treated with the long‐acting
somatostatin analogue octreotide (SMS 201–995). Three patients showed no response …

The treatment of patients with Zollinger-Ellison syndrome (ZES) has undergone dramatic
evolution during the past decade. Although initially regarded as an incurable tumor …

GAWK (chromogranin-B 420-493) is a 74 amino acid peptide recently isolated from human
pituitaries. Using two different antibodies (directed against GAWK [1-17] and [20-38] …

With the recent widespread availability of gastrin radioimmunoassays, the development of
increasingly effective medical therapy for gastric hypersecretion, and improved methods to …

Symptomatic endocrine abnormalities in malignant disease may arise either from deficiency
states or from the inappropriate or ectopic secretion of a hormone. The clinical picture of the …

Investigations were carried out on mammary carcinoma 5A (MC) with the objective of
elucidating mechanisms underlying alterations in bone marrow function caused by non …