Approximately 70 percent of the mutations in cystic fibrosis patients correspond to a specific
deletion of three base pairs, which results in the loss of a phenylalanine residue at amino …

An understanding of the basic defect in the inherited disorder cystic fibrosis requires cloning
of the cystic fibrosis gene and definition of its protein product. In the absence of direct …

The pancreases of 23 patients (mean age 10.5 years, range 5-22) years dying of cystic
fibrosis (CF) were evaluated at autopsy by routine histology and immunostaining for …

Patients with cystic fibrosis (CF) generally suffer from chronic obstructive lung disease,
pancreatic insufficiency (PI), and a number of other exocrine malfunctions. Approximately …

L.-C. Tsui M. Farrall H. Donis-Keller CHROMOSOME 7 There are a total of 94 gene loci, 410
DNA segments and 10 fragile sites listed on this chromosome at HGM10. Of these, 9 are …

Strong linkage disequilibrium occurs between the cystic fibrosis (CF) locus and
polymorphisms detected with the DNA probes XV-2c and KM-19. In a North American …

We have developed an X-irradiation: cell fusion procedure that segregates segments of
human chromosomes lacking selectable markers and have used this approach to construct …

We have used a recombinant phage library enriched for chromosome 22 sequences to
isolate and characterize eight anonymous DNA probes detecting restriction fragment length …

Seventeen patients with cystic fibrosis and 17 age-, race-, and sex-matched controls were
examined under standardized conditions. Testing included slit-lamp biomicroscopy …

Strong linkage disequilibrium (LD) was found between DNA marker XV2c and the cystic
fibrosis (CF) locus (delta= 0.46) and between DNA marker KM19 and CF (delta= 0.67) in …