Ibotenate lesions of hippocampus and/or subiculum: dissociating components of allocentric spatial learning

RGM Morris, F Schenk, F Tweedie… - European Journal of …, 1990 - Wiley Online Library
This study examined the effects of ibotenic acid‐induced lesions of the hippocampus,
subiculum and hippocampus±subiculum upon the capacity of rats to learn and perform a …

Hippocampal representation in place learning

H Eichenbaum, C Stewart, RG Morris - Journal of Neuroscience, 1990 - Soc Neuroscience
The generality of the place-learning impairment associated with hippocampal system
damage was challenged using methods of training that permitted subjects to form an …

Evolution of spatial cognition: sex-specific patterns of spatial behavior predict hippocampal size.

LF Jacobs, SJ Gaulin, DF Sherry… - Proceedings of the …, 1990 - National Acad Sciences
In a study of two congeneric rodent species, sex differences in hippocampal size were
predicted by sex-specific patterns of spatial cognition. Hippocampal size is known to …

Hippocampus, amygdala, and memory deficits in rats

RJ Sutherland, RJ McDonald - Behavioural brain research, 1990 - Elsevier
Five experiments were conducted to compare the contribution of the hippocampal formation
and amygdala to mnemonic processes. The performance of rats with damage to the …

Hippocampal protein kinase C activity is reduced in poor spatial learners

JM Wehner, S Sleight, M Upchurch - Brain research, 1990 - Elsevier
Activation of protein kinase C (PKC) via neurotransmitter coupling processes has been
associated with long-term potentiation (LTP) or classical conditioning, but whether natural …

Why NMDA-receptor-dependent long-term potentiation may not be a mechanism of learning and memory: Reappraisal of the NMDA-receptor blockade strategy

JR Keith, JW Rudy - Psychobiology, 1990 - Springer
The hypothesis that the processes mediating the induction of long-term potentiation (LTP) in
the hippocampus also subserve hippocampally mediated learning and memory has recently …

Domoic acid, an environmental toxin, produces hippocampal damage and severe memory impairment

RJ Sutherland, JM Hoesing, IQ Whishaw - Neuroscience letters, 1990 - Elsevier
Microinjections of domoic acid, a presumed shellfish toxin, into the hippocampal formation of
rats produces degeneration of CA3 and CA1 pyramidal cells and dentate gyrus granule …

The relationship of structural ischemic brain damage to neurobehavioural deficit: the effect of postischemic MK-801.

MR Rod, IQ Whishaw, RN Auer - Canadian Journal of Psychology …, 1990 - psycnet.apa.org
L'ischémie cérébral globale provoque généralement une nécrose neurale dans des régions
particulièrement vulnérables de l'hippocampe. Etant donné que cette structure est impliquée …

A further characterization of the spatial problem-solving deficit induced by lesions of the medial frontal cortex in the rat

B Poucet - Behavioural Brain Research, 1990 - Elsevier
Two experiments were conducted to investigate the basis of the spatial impairment
displayed by rats with lesions to the medial frontal cortex, using a three-table Y-shaped …

Effects of N-methyl-d-aspartate antagonism on spatial learning in mice

M Upchurch, JM Wehner - Psychopharmacology, 1990 - Springer
C57BL/6Ibg mice were treated with the N-methyl-d-aspartate (NMDA) receptor antagonist 3-
(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid (CPP) and tested for selective deficits in …