Dynamics of the distribution of cyclic AMP-dependent protein kinase in living cells.
JL Meinkoth, Y Ji, SS Taylor… - Proceedings of the …, 1990 - National Acad Sciences
The intracellular distribution of regulatory molecules may provide a mechanism for
controlling gene expression. The subcellular location of cAMP-dependent protein kinase …
controlling gene expression. The subcellular location of cAMP-dependent protein kinase …
Synthetic peptides of the hamster beta 2‐adrenoceptor as substrates and inhibitors of the beta‐adrenoceptor kinase.
JL Benovic, J Onorato, MJ Lohse… - British journal of …, 1990 - Wiley Online Library
1. The beta‐adrenoceptor is one of a number of G protein‐coupled receptors which have
been proposed to contain seven transmembrane alpha‐helices. The function of this receptor …
been proposed to contain seven transmembrane alpha‐helices. The function of this receptor …
[HTML][HTML] Dissecting the domain structure of the regulatory subunit of cAMP-dependent protein kinase I and elucidating the role of MgATP.
GE Ringheim, SS Taylor - Journal of Biological Chemistry, 1990 - Elsevier
A truncated regulatory subunit of cAMP-dependent protein kinase I was constructed which
contained deletions at both the carboxyl terminus and at the amino terminus. The entire …
contained deletions at both the carboxyl terminus and at the amino terminus. The entire …
[HTML][HTML] Effects of cAMP-binding site mutations on intradomain cross-communication in the regulatory subunit of cAMP-dependent protein kinase I.
GE Ringheim, SS Taylor - Journal of Biological Chemistry, 1990 - Elsevier
Each protomer of the regulatory subunit dimer of cAMP-dependent protein kinase contains
two tandem and homologous cAMP-binding domains, A and B, and cooperative cAMP …
two tandem and homologous cAMP-binding domains, A and B, and cooperative cAMP …
Evaluation of kemptide, a synthetic serinecontaining heptapeptide, as a phosphate acceptor for the estimation of cyclic AMP-dependent protein kinase activity in …
MA Giembycz, J Diamond - Biochemical pharmacology, 1990 - Elsevier
In the search for a phosphate acceptor to estimate cyclic AMP-dependent protein kinase (A-
kinase) activity in respiratory tissues devoid of the disadvantages inherent with the use of …
kinase) activity in respiratory tissues devoid of the disadvantages inherent with the use of …
[HTML][HTML] Noncovalent active site interactions enhance the affinity and control the binding order of reversible inhibitors of the cAMP-dependent protein kinase.
A Salerno, M Mendelow, M Prorok… - Journal of Biological …, 1990 - Elsevier
The peptides, Leu-Arg-Arg-Ala-Ala-Leu-Gly-NH2, Leu-Arg-Arg-Gln-Ala-Leu-Gly-NH2, and
Leu-Arg-Arg-Asn-Ala-Leu-Gly-NH2, serve as active site-directed inhibitors of the cAMP …
Leu-Arg-Arg-Asn-Ala-Leu-Gly-NH2, serve as active site-directed inhibitors of the cAMP …
Determination of soluble cAMP-dependent protein kinase activity in guinea-pig tracheal smooth muscle: preferential use of kemptide as a phosphorylating substrate
JM Langlands, IW Rodger - Biochemical pharmacology, 1990 - Elsevier
A method is described for the determination of soluble (cytosolic) cyclic AMP (cAMP)-
dependent protein kinase (A-kinase) activity in guinea-pig tracheal smooth muscle. The …
dependent protein kinase (A-kinase) activity in guinea-pig tracheal smooth muscle. The …
Partial characterization of cyclic AMP-dependent protein kinases in guinea-pig lung employing the synthetic heptapeptide substrate, Kemptide: In vitro sensitivity of the …
MA Giembycz, J Diamond - Biochemical pharmacology, 1990 - Elsevier
This paper describes the partial characterization of soluble cyclic AMP-dependent protein
kinase (A-kinase) in guinea-pig lung using Kemptide, a synthetic serine-containing …
kinase (A-kinase) in guinea-pig lung using Kemptide, a synthetic serine-containing …