The striatum, which is the major component of the basal ganglia in the brain, is regulated in
part by dopaminergic input from the substantia nigra. Severe movement disorders result …

Within the basal ganglia, acetylcholine and dopamine play a central role in the
extrapyramidal control of motor function. The physiologic effects of these neurotransmitters …

In situ hybridization with D 2 receptor probe and immunohistochemistry with choline
acetyltransferase (ChAT) antibody performed on adjacent sections demonstrate dopamine D …

The catecholamine dopamine plays an important role as a neurotransmitter or
neurohormone in the brain and pituitary gland. Dopamine exerts its effects through …

Significant new information on the 1) 2 dopamine receptor has recently become available
from a combination of protein chemical and molecular genetic analyses. Molecular genetic …

In situ hybridization was used to study dopamine D2 receptor (D2R) and choline
acetyltransferase (ChAT) mRNA expression in neurons of the rat forebrain, both on control …

Chronic administration of the neuroleptic drug haloperidol previously has been shown to
increase the density of striatal dopamine D 2 receptor, which is believed to be the underlying …

We used oligonucleotide probes to isolate cDNAs that encode two subtypes of D2 dopamine
receptors (“D2 long” and “D2 short”). In situ hybridization histochemistry with cRNA probes …

This review will focus on the main lines of evidence that suggest the existence of multiple
types of dopamine D-2 receptors. Dopamine D-2 receptors share structural elements …

Fig. 1. Effects of chronic haloperidol treatment (n= 4) or of unilateral 6-hydroxydopamine (6-
OHDA) lesions of nigrostriatal dopamine neurons (n= 7) on dopamine D 2 mRNA levels (a) …