Calcium/calmodulin-dependent protein kinase II

RJ Colbran, TR Soderling - Current topics in cellular regulation, 1990 - Elsevier
Publisher Summary This chapter discusses the presently known calcium (Ca 2+)/calmodulin
(CaM)-dependent protein kinases and some of their properties. To date, CaM kinase II is the …

[HTML][HTML] Calcium/calmodulin-independent autophosphorylation sites of calcium/calmodulin-dependent protein kinase II. Studies on the effect of phosphorylation of …

RJ Colbran, TR Soderling - Journal of Biological Chemistry, 1990 - Elsevier
Two synthetic peptides containing the previously identified calmodulin (CaM)-binding
domain of Ca2+/CaM-dependent protein kinase II (CaM-kinase II)(residues 296-309, Payne …

[HTML][HTML] Activation of type II calcium/calmodulin-dependent protein kinase by Ca2+/calmodulin is inhibited by autophosphorylation of threonine within the calmodulin …

BL Patton, SG Miller, MB Kennedy - Journal of Biological Chemistry, 1990 - Elsevier
It is now well established that autophosphorylation of a threonine residue located next to
each calmodulin-binding domain in the subunits of type II Ca2+/calmodulin-dependent …

Multifunctional calcium/calmodulin-dependent protein kinase made calcium-independent for functional studies

R Waldmann, PI Hanson, H Schulman - Biochemistry, 1990 - ACS Publications
Department of Pharmacology, Stanford University School of Medicine, Stanford, California
94025-5332 Received November 15, 1989; Revised Manuscript Received December 11 …

Protein‐protein recognition via short amphiphilic helices; a mutational analysis of the binding site of annexin II for p11.

T Becker, K Weber, N Johnsson - The EMBO journal, 1990 - embopress.org
Annexin II (p36) interacts with its ligand p11 via the short stretch of 12 amino acids (Ac‐S‐T‐
V‐H‐E‐I‐L‐C‐K‐L‐S‐L) situated at the N‐terminus. We have now synthesized some 37 …

Multifunctional Ca2+/calmodulin-dependent protein kinase is necessary for nuclear envelope breakdown.

C Baitinger, J Alderton, M Poenie, H Schulman… - The Journal of cell …, 1990 - rupress.org
The role of multifunctional Ca2+/calmodulin-dependent protein kinase (CaM kinase) in
nuclear envelope breakdown (NEB) was investigated in sea urchin eggs. The eggs contain …

Use of DNA sequence and mutant analyses and antisense oligodeoxynucleotides to examine the molecular basis of nonmuscle myosin light chain kinase …

MO Shoemaker, W Lau, RL Shattuck… - The Journal of cell …, 1990 - rupress.org
The first primary structure for a nonmuscle myosin light chain kinase (nmMLCK) has been
determined by elucidation of the cDNA sequence encoding the protein kinase from chicken …

[HTML][HTML] Ca2+/calmodulin kinase is activated by the phosphatidylinositol signaling pathway and becomes Ca2 (+)-independent in PC12 cells.

M MacNicol, AB Jefferson, H Schulman - Journal of Biological Chemistry, 1990 - Elsevier
Hormonal activation of the phosphatidylinositol (PI) signaling system initiates a biochemical
pathway that bifurcates to increase cellular levels of diacylglycerol and of inositol …

Mutagenesis of Thr-286 in monomeric Ca2+/calmodulin-dependent protein kinase II eliminates Ca2+/calmodulin-independent activity.

MN Waxham, J Aronowski… - Proceedings of the …, 1990 - National Acad Sciences
We have examined the role of Thr-286 autophosphorylation in the autoregulation of
Ca2+/calmodulin-dependent protein kinase II. Using site-directed mutagenesis, we have …

Expression and characterization of the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II using the baculovirus expression system

DA Brickey, RJ Colbran, YL Fong… - … and biophysical research …, 1990 - Elsevier
Sf9 cells infected with the recombinant mouse CaMKII-α (Ca 2+/calmodulin dependent
kinase II) baculovirus expressed 12–15 mg of MCaMKII-α per liter of cells. Approximately …