The concept of pancreatic β-cell mass is fundamental to the understanding of normal
metabolism, the pathogenesis of diabetes, and the transplantation of β-cell tissue. The …

Amylin, a peptide copackaged with insulin in beta-cell granules, was measured in the
effluent of the perfused rat pancreases by means of a newly developed specific …

Islet amyloid may have a pathological role in the development of Type 2 (non-insulin-
dependent) diabetes mellitus. The prevalence of islet amyloid has been investigated on post …

Cats and humans, unlike most rodent species, develop amyloid in the islets of Langerhans
in conjunction with non-insulin-dependent diabetes mellitus. The amyloid consists of a 37 …

Conclusions Two newly discovered peptides, CGRP and amylin, have both been
demonstrated to occur in the pancreas: CGRP in nerves and endocrine cells and amylin in …

Amylin, a 37 amino acid C-terminal amidated peptide is an integral part of secretory
granules of pancreatic β-cells. Utilizing a specific radioimmunoassay system we …

The degu, Octodon degus, is a South American hystricomorph rodent that is of interest
because it develops spontaneous diabetes mellitus and has been found to have islet …

Amylin, a 37-amino acid polypeptide, is the main component of amyloid deposits in the islets
of Langerhans, and has been identified in the B-cell secretory granules. We have …

Amylin amide, a 37-amino acid peptide that is a major component of amyloid deposits in the
diabetic pancreas, possesses vasodilator activity. Human synthetic amylin amide (30 to 300 …

The effects of amylin on glucose metabolism and glycogenolysis were examined in vivo and
in vitro. Eighteen-hour-fasted rats were infused with 5 nmol. kg-1. min-1 amylin and [3-3H] …