The costimulatory function of antigen-presenting cells
CT Weaver, ER Unanue - Immunology today, 1990 - Elsevier
In addition to the expression of MHC-antigen complexes and molecules which non-
specifically promote cell adhesion, antigen-presenting cells (APCs) provide costimutalory …
specifically promote cell adhesion, antigen-presenting cells (APCs) provide costimutalory …
Virus-induced autoimmunity
A Schattner, B Rager-Zisman - Reviews of infectious diseases, 1990 - academic.oup.com
Viral infections in humans commonly result in the transient appearance of a variety of
autoantibodies and, in some patients, the development of autoimmune tissue injury and …
autoantibodies and, in some patients, the development of autoimmune tissue injury and …
Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response
ER Fearon, DM Pardoll, T Itaya, P Golumbek… - Cell, 1990 - cell.com
A poorly immunogenic murine colon cancer was used to investigate mechanisms of
antitumor immunity. Injection of tumor cells engineered by gene transfection to secrete IL-2 …
antitumor immunity. Injection of tumor cells engineered by gene transfection to secrete IL-2 …
Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity
The mechanism by which T lymphocytes an? tolerized to self or foreign antigens is still
controversial. Clonal deletion is the major mechanism of tolerance for immature thymocytes; …
controversial. Clonal deletion is the major mechanism of tolerance for immature thymocytes; …
Peripheral clonal elimination of functional T cells
LA Jones, LT Chin, DL Longo, AM Kruisbeek - Science, 1990 - science.org
A major mechanism for generating tolerance in developing T cells is the intrathymic clonal
deletion of T cells that have receptors for those self antigens that are presented on …
deletion of T cells that have receptors for those self antigens that are presented on …
Comparison of cytokine effects on mouse pancreatic α-cell and β-cell lines viability, secretory function, and mhc antigen expression
K Hamaguchi, EH Leiter - Diabetes, 1990 - Am Diabetes Assoc
Cytokine effects on permanent cell lines of transformed mouse pancreatic α-and β-cells
were compared. The β–tumor cell 1 (βTC1) line (from an adenoma created in transgenic …
were compared. The β–tumor cell 1 (βTC1) line (from an adenoma created in transgenic …
A role for clonal inactivation in T cell tolerance to Mis-1a
MA Blackman, H Gerhard-Burgert, DL Woodland… - Nature, 1990 - nature.com
CLONAL deletion plays a major part in the maintenance of natural self-tolerance in both
normal1–5 and transgenic6–9 mice. Self antigens that are expressed in the thymus result in …
normal1–5 and transgenic6–9 mice. Self antigens that are expressed in the thymus result in …
T cell reactivity to MHC molecules: immunity versus tolerance
J Sprent, EK Gao, SR Webb - Science, 1990 - science.org
The specificity of mature CD8+ and CD4+ T lymphocytes is controlled by major
histocompatibility complex (MHC) class I and class II molecules, respectively. The MHC …
histocompatibility complex (MHC) class I and class II molecules, respectively. The MHC …
Tolerance in transgenic mice expressing major histocompatibility molecules extrathymically on pancreatic cells
LC Burkly, D Lo, RA Flavell - Science, 1990 - science.org
Transgenic mice with defined expression of major histocompatibility complex (MHC)
proteins provide novel systems for understanding the fundamental question of T cell …
proteins provide novel systems for understanding the fundamental question of T cell …
The expression of influenza virus hemagglutinin in the pancreatic β cells of transgenic mice results in autoimmune diabetes
LM Roman, LF Simons, RE Hammer, JF Sambrook… - Cell, 1990 - cell.com
Insulin-dependent diabetes mellitus results from the autoimmune destruction of the insulin-
producing 5 ceils of the pancreatic islets. The target antigen (s) involved in this …
producing 5 ceils of the pancreatic islets. The target antigen (s) involved in this …