In addition to the expression of MHC-antigen complexes and molecules which non-
specifically promote cell adhesion, antigen-presenting cells (APCs) provide costimutalory …

Viral infections in humans commonly result in the transient appearance of a variety of
autoantibodies and, in some patients, the development of autoimmune tissue injury and …

A poorly immunogenic murine colon cancer was used to investigate mechanisms of
antitumor immunity. Injection of tumor cells engineered by gene transfection to secrete IL-2 …

The mechanism by which T lymphocytes an? tolerized to self or foreign antigens is still
controversial. Clonal deletion is the major mechanism of tolerance for immature thymocytes; …

A major mechanism for generating tolerance in developing T cells is the intrathymic clonal
deletion of T cells that have receptors for those self antigens that are presented on …

Cytokine effects on permanent cell lines of transformed mouse pancreatic α-and β-cells
were compared. The β–tumor cell 1 (βTC1) line (from an adenoma created in transgenic …

CLONAL deletion plays a major part in the maintenance of natural self-tolerance in both
normal1–5 and transgenic6–9 mice. Self antigens that are expressed in the thymus result in …

The specificity of mature CD8+ and CD4+ T lymphocytes is controlled by major
histocompatibility complex (MHC) class I and class II molecules, respectively. The MHC …

Transgenic mice with defined expression of major histocompatibility complex (MHC)
proteins provide novel systems for understanding the fundamental question of T cell …

Insulin-dependent diabetes mellitus results from the autoimmune destruction of the insulin-
producing 5 ceils of the pancreatic islets. The target antigen (s) involved in this …