During recent decades it has become feasible to simulate the dynamics of molecular
systems on a computer. The method of molecular dynamics (MD) solves Newton's equations …

Structural studies of DNA-binding proteins and their complexes with DNA have proceeded at
an accelerating pace in recent years due to important technical advances in molecular …

A chemical description of the action of phospholipase A2 (PLA2) can now be inferred with
confidence from three high-resolution x-ray crystal structures. The first is the structure of the …

The crystal structure of a complex containing the engrailed homeodom $ n and a duplex
DNA site has been determlned at 2.8 A resolution and refined to a crystallographic R factor …

U. maydis is a fungal pathogen of corn with two forms: one is yeast-like and nonpathogenic;
the other is filamentous and pathogenic. The b locus, with 25 different alleles, regulates this …

Fifty high resolution protein structures from the Brookhaven Protein Data Bank have been
analyzed for recurring motifs in hydrogen bond stereochemistry. Although an exhaustive …

A class of transcriptional regulator proteins bind to DNA at dyad-symmetric sites through a
motif consisting of (i) a" leucine zipper" sequence that associates into noncovalent, parallel …

High sequence selectivity in DNA-protein interactions was analyzed by measuring
discrimination by Eco RI endonuclease between the recognition site GAATTC and …

Two-dimensional nuclear Overhauser effect spectroscopy (NOESY) was used to study the
interactionof distamycin A with d (CGCAAATTTGCG) j. Spectra acquired at several points in …

The in vitro DNA binding properties of a purified 68-amino acid Antennapedia
homeodomain (Antp HD) peptide have been analyzed. Equilibrium and kinetic binding …