Environmental, occupational, and recreational exposures to carcinogens contribute to
cancer risk in humans. Cancer formation is a multistage process involving tumor initiation …

Genetic modulation of environmental exposures associated with common malignancies
(lung and bladder) is an attractive mechanism to explain differential susceptibility to tobacco …

A specific member of the cytochrome P450 super‐family of enzymes, designated P450IA
(including 2 isozymes, P450IAI and P450IA2), which is involved in the metabolic activation …

Most of the chemical carcinogens in our environment are activated mainly by a restricted
number of cytochrome P450 species, P450 1A1, 1A2, 2E1, and 3A. This metabolic activation …

Twelve human cytochrome P450s and one mouse P450 were produced in HepG2 cells
using vaccinia virus cDNA expression and analyzed for their ability to bioactivate the …

The cytochromes P450 are a multigene super-family of enzymes, existing as multiple forms,
which metabolise a wide variety of xenobioticsand endogenous compounds including …

Cytotoxic drugs have become invaluable for the clinical oncologist in the treatment of
neoplastic disease. Frequently, these therapeutic agents are used in combination in order to …

Individual variations in activity of pulmonary enzymes that metabolize tobacco-derived
carcinogens may affect an individual's cancer risk from cigarette smoking. To investigate …

Data from animal studies suggest that cytochrome P450IA1 catalyses the metabolic
activation of several procarcinogenic compounds. In the present study, we have expressed …

The lung is a primary site of exposure to airborne and blood-borne environmental pollutants
and carcinogens including polycyclic aromatic hydrocarbons (PAHs), and is a target organ …