Evidence for the formation of nitrenium ions in the acid-catalysed solvolysis of mutagenic N-acetoxy-N-alkoxybenzamides
JJ Campbell, SA Glover, GP Hammond… - Journal of the …, 1991 - pubs.rsc.org
In aqueous acetonitrile, N-acetoxy-N-alkoxybenzamides undergo acid-catalysed solvolysis
by the AAl1 mechanism to give acetic acid and nitrenium ions. This is indicated by an …
by the AAl1 mechanism to give acetic acid and nitrenium ions. This is indicated by an …
Synthetic transformations using arenesulfonyloxy groups, first as electrophiles, then as leaving groups
RV Hoffman - Tetrahedron, 1991 - Elsevier
1. Inl,'oduclion A pervasive methtxI for the fomlation of new bonds is to react an electron rich
reagent (nucleophile) with a substrate (electrophile) containing an electmnegative atom or …
reagent (nucleophile) with a substrate (electrophile) containing an electmnegative atom or …
A simple, one-flask transformation of ketones to N-methyl lactams
RV Hoffman, JM Salvador - Tetrahedron letters, 1991 - Elsevier
A one-flask conversion of cyclic ketones to N-methyl lactams is described. Reaction of the
ketone with triethylorthoformate generates an acetal which is reacted in situ with N-(((p …
ketone with triethylorthoformate generates an acetal which is reacted in situ with N-(((p …