The application of molecular biology to problems in diabetes mellitus has begun to reveal
the underlying molecular defects contributing to the development of hyperglycemia. Islet …

Antibodies specific for the insulin-regulatable glucose transporter (GLUT 4) were used to
immunolocalize this protein in brown adipose tissue from basal-and insulin-treated rats …

Materials and Methods Materials. Collagenase was obtained from Worthington Scientific Ltd.
Sodium diguanosine triphosphate was pur-chased from Pharmacia. SP6 polymerase …

A major portion of insulin-mediated glucose uptake occurs via the translocation of GLUT 4
glucose transporter proteins from an intracellular depot to the plasma membrane. We have …

The insulin-regulated glucose transporter GLUT4 was immunolocalized in rat cardiac
muscle under conditions of basal and stimulated glucose uptake, achieved by fasting and a …

To elucidate a functional role of N-glycosylation in glucose transporters, we introduced
oligonucleotide-directed mutagenesis in GLUT1 cDNA to remove the possible site for N …

Exercise training has been proposed to improve whole body insulin sensitivity through a
postreceptor adaptation in skeletal muscle. This study examined if levels of the insulin …

Evidence is emerging for a direct role of glucose, independent of changes in insulin, in the
regulation of cellular glucose transport and glucose utilization in vivo. In this study we …

Skeletal muscle is the main tissue responsible for glucose utilization in the fed state, and it
expresses the ubiquitous GLUT1 glucose transporter and the muscle/fat specific GLUT4 …

Insulin-stimulated glucose uptake into muscle and fat involves regulation of the subcellular
distribution and the expression of a specific facilitative glucose transporter protein (GLUT4) …