Cytisine, a ganglionic agonist, competes with high affinity for brain nicotinic cholinergic
receptors labeled by any of several nicotinic 3H-agonist ligands. Here we have examined …

Myasthenia gravis (MG) is caused by autoantibodies against the nicotinic acetylcholine
receptor (AChR) of the neuromuscular junction. The anti-AChR antibodies are …

Classical transmitters are present in all phyla that have been studied; however, our detailed
understanding of the process of neurotransmission in these phyla is patchy and has centred …

Materials and Methods Materials. L-[3H] Nicotine(N-methyl-[3H], specific activity 63.5 Ci!
mmol) was purchased from Amersham Corp.(Arlington Heights, IL) and.[mnIbungaroxin(r …

Eighteen analogs of (+)-anatoxin-a were evaluated for nicotinic potency at two putative
nicotinic acetylcholine receptor sites in the central nervous system. The affinities of the …

Several studies have demonstrated that chronic treatment with nicotine elicits an increase in
the number of brain nicotinic receptors. To determine whether this effect is elicited by other …

We previously reported that activation of muscarinic acetylcholine receptors (mAChR) of M3
subtype causes hydrolysis of phosphoinositides and inhibits voltage-gated Ca2+ channel …

Alcoholics are almost invariably heavy users of tobacco. Both alcoholism and smoking
appear to be influenced by genetic factors but it is not known whether the same or different …

The relationship between neuronal alpha-bungarotoxin binding proteins (alpha BGTBPs)
and nicotinic acetylcholine receptor function in the brain of higher vertebrates has remained …

Society must deal with the dangerous dichotomy of drugs, a dichotomy that arises from the
fact that the drugs that provide the best treatment for many illnesses also present …