MPTP mechanisms of neurotoxicity and their implications for Parkinson's disease
M Gerlach, P Riederer, H Przuntek… - European Journal of …, 1991 - Elsevier
Abstract Systemic administration of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)
gives rise to motor deficits in humans and other primates which closely resemble those seen …
gives rise to motor deficits in humans and other primates which closely resemble those seen …
Rescue of dying neurons: a new action for deprenyl in MPTP parkinsonism
WG Tatton, CE Greenwood - Journal of neuroscience research, 1991 - Wiley Online Library
Deprenyl slows the progression of disabling symptoms in Parkinson's disease (PD) by an
unknown mechanism. It can block the action of MPTP on substantia nigra compacta (SNc) …
unknown mechanism. It can block the action of MPTP on substantia nigra compacta (SNc) …
Different rates of age-related loss for four murine monoaminergic neuronal populations
WG Tatton, CE Greenwood, MC Verrier, DP Holland… - Neurobiology of …, 1991 - Elsevier
The age-related loss of locus coeruleus (LC) noradrenergic neurons, substantia nigra
compacta (SNc) dopaminergic neurons, dopaminergic retinal amacrine (rAm) neurons and …
compacta (SNc) dopaminergic neurons, dopaminergic retinal amacrine (rAm) neurons and …
Increased dopamine synthesis in aging substantia nigra neurons
CE Greenwood, WG Tatton, NA Seniuk, FG Biddle - Neurobiology of aging, 1991 - Elsevier
Striatal dopamine (DA) and metabolite (DOPAC) levels in 8-, 21-, 52-and 104-week-old
C57BL mice were compared with those in 11-week-old mice, 20 days after 1-methyl-4 …
C57BL mice were compared with those in 11-week-old mice, 20 days after 1-methyl-4 …
Neurotoxic effects of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine in the substantia nigra and the locus coeruleus in BALB/c mice.
The purpose of the present study was to determine whether 1-methyl-4-phenyl-1, 2, 3, 6-
tetrahydropyridine (MPTP), administered systemically or as a local infusion, has a direct …
tetrahydropyridine (MPTP), administered systemically or as a local infusion, has a direct …
Transmitter synthesis increases in substantia nigra neurons of the aged mouse
WG Tatton, CE Greenwood, PT Salo, NA Seniuk - Neuroscience letters, 1991 - Elsevier
Striatal dopamine concentrations are relatively well maintained with age despite extensive
death of the nigrostriatal neurons whose terminals contain the dopamine. Counts of …
death of the nigrostriatal neurons whose terminals contain the dopamine. Counts of …