The consumption of pyruvate and glucose, and the production of lactate, by single
preimplantation embryos, was measured using a noninvasive technique. Embryos were …

We have previously developed a technique of trophectoderm biopsy to obtain cells from
human blastocysts for preimplantation genetic diagnosis. To determine whether this …

The embryonic factors influencing implantation have been studied extensively in laboratory
and domestic animals, but not in primates, including humans. Species differences make …

Objective To assess embryo viability after ultrarapid freezing-thawing. Design We studied
the fluorescence pattern of 35 ultrarapidly frozen-thawed multipronucleate human embryos …

For the preimplantation diagnosis of inherited disease by DNA analysis, a cell or cells must
be biopsied from each embryo. With established techniques for in vitro fertilization (IVF) …

The profiles of hypoxanthine guanine phosphoribosyl transferase (HGPRT) and adenine
phosphoribosyl transferase (APRT) activities were examined in normally fertilized human …

The advent of the new reproductive technologies (including in vitro fertilization) has led to a
revolution in the treatment of infertility. It has not yet led to a marked improvement in our …

Successful embryo implantation in the human involves a complex interaction between the
hatched blastocyst and the luteal phase endometrium. The physiological aspects of this …

The nonhuman primates occupy a unique niche among species suitable for experimental
studies on fertilization and early development. Studies with nonhuman primates provide an …

Genetic risk for offspring of some couples is high. One in four of their children will be affected
if both parents carry the same recessive gene, one in two if one parent carries a dominant …