Mechanisms of the analgesic actions of opiates and opioids
AH Dickenson - British medical bulletin, 1991 - academic.oup.com
It is now clear that there are three sub-types of the opiate receptor, mu, delta and kappa.
Evidence for differential roles of those sub-types in pain modulation is accumulating since …
Evidence for differential roles of those sub-types in pain modulation is accumulating since …
Spinal opioid analgesic effects are enhanced in a model of unilateral inflammation/hyperalgesia: possible involvement of noradrenergic mechanisms
JLK Hylden, DA Thomas, MJ Iadarola, RL Nahin… - European journal of …, 1991 - Elsevier
We have examined the spinal analgesic activity of opioid agonists and antagonists in a
model of short term, unilateral, carrageenan-induced inflammation/hyperalgesia. Rats …
model of short term, unilateral, carrageenan-induced inflammation/hyperalgesia. Rats …
Stereospecific effects of a nonpeptidic NK1 selective antagonist, CP-96,345: antinociception in the absence of motor dysfunction
T Yamamoto, TL Yaksh - Life sciences, 1991 - Elsevier
Abstract CP-96,345 has been identified as being a highly selective, nonpeptidic agent with
subnanomolar affinity for the NK1 receptor. In the present study, we observed that pre but …
subnanomolar affinity for the NK1 receptor. In the present study, we observed that pre but …
Release of substance P into the superficial dorsal horn following nociceptive activation of the hindpaw of the rat
KE McCarson, BD Goldstein - Brain research, 1991 - Elsevier
Substance P (SP) has been widely proposed as being involved in the transmission of
nociceptive information in the dorsal horn of the spinal cord. Formalin injected into the …
nociceptive information in the dorsal horn of the spinal cord. Formalin injected into the …
Catecholaminergic innervation of the spinal dorsal horn: a correlated light and electron microscopic analysis of tyrosine hydroxylase-immunoreactive fibres in the cat
CA Doyle, DJ Maxwell - Neuroscience, 1991 - Elsevier
The ultrastructural organization of presumed catecholamine-containing boutons, in the
dorsal horn of the cat lumbosacral spinal cord, was examined in an immunocytochemical …
dorsal horn of the cat lumbosacral spinal cord, was examined in an immunocytochemical …
Differential contribution of descending serotonergic and noradrenergic systems to central Tyr-D-Ala2-Gly-NMePhe4-Gly-ol5 (DAMGO) and morphine-induced …
KS Arts, BB Holmes, JM Fujimoto - Journal of Pharmacology and …, 1991 - ASPET
Differences in antinociceptive (inhibition of tail-flick response) action of morphine and Tyr-D-
Ala2-Gly-NMePhe4-ol5 (DAMGO) were demonstrated by intracerebroventricular (icv) …
Ala2-Gly-NMePhe4-ol5 (DAMGO) were demonstrated by intracerebroventricular (icv) …
Ultrastructural analysis of noradrenergic nerve terminals in the cat lumbosacral spinal dorsal horn: a dopamine-β-hydroxylase immunocytochemical study
CA Doyle, DJ Maxwell - Brain research, 1991 - Elsevier
Noradrenaline-containing nerve terminals within the cat spinal dorsal horn were studied by
immunocytochemical localization of dopamine-β-hydroxylase. Immunoreactive terminals …
immunocytochemical localization of dopamine-β-hydroxylase. Immunoreactive terminals …
[PDF][PDF] Intracerebroventricular morphine releases adenosine and adenosine 3', 5'-cyclic monophosphate from the spinal cord via a serotonergic mechanism.
MI Sweeney, TD White, J Sawynok - Journal of Pharmacology and …, 1991 - Citeseer
ABSTRACT ABBREVIATIONS: it., intrathecal; NE, norepinephnne; 5-HT, 5-
hydroxytryptamine; CSF, cerebrospinal fluid; HPLC, high-performance liquid …
hydroxytryptamine; CSF, cerebrospinal fluid; HPLC, high-performance liquid …
[PDF][PDF] Different mechanisms mediating tail-flick inhibition induced by beta-endorphin, DAMGO and morphine from ROb and GiA in anesthetized rats.
LF Tseng, KA Collins - Journal of Pharmacology and Experimental …, 1991 - Citeseer
The effects of f.-endorphin, D-Ala2-NMePhe4-GIy-0I-eflkephalifl (DAMGO) and morphine
microinjected into raphe obscurus nucleus (ROb) and gigantocellular reticular nucleus …
microinjected into raphe obscurus nucleus (ROb) and gigantocellular reticular nucleus …
Comparison of the antinociceptive and motor effects of intrathecal opioid agonists in the rat
C Miaskowski, KA Sutters, YO Taiwo, JD Levine - Brain research, 1991 - Elsevier
This study compared the antinociceptive and motor effects produced by intrathecal
administration of selective μ-, δ-, and κ-opioid receptor agonists in the rat. Changes in …
administration of selective μ-, δ-, and κ-opioid receptor agonists in the rat. Changes in …