Immunopathogenic mechanisms in human immunodeficiency virus (HIV) infection

AS Fauci, SM Schnittman, G Poli, S Koenig… - Annals of internal …, 1991 - acpjournals.org
An understanding of the immunopathogenic mechanisms of infection with human
immunodeficiency virus (HIV) is fundamental in developing successful approaches to …

Molecular biology of the human immunodeficiency virus type 1

WA Haseltine - The FASEB journal, 1991 - Wiley Online Library
The immunodeficiency virus type 1 is a complex retrovirus. In addition to genes that specify
the proteins of the virus particle and the replicative enzymes common to all retroviruses, HIV …

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

JV Garcia, AD Miller - Nature, 1991 - nature.com
Abstract A DECLINE in the T-cell population usually marks the onset of progressive
immunological disease in individuals infected with the human immunodeficiency virus (HIV) …

Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins.

RK Williams, GS Jiang… - Proceedings of the …, 1991 - National Acad Sciences
The receptor for mouse hepatitis virus (MHV), a murine coronavirus, is a 110-to 120-kDa
glycoprotein on intestinal brush border membranes and hepatocyte membranes. The N …

Bispecific single chain molecules (Janusins) target cytotoxic lymphocytes on HIV infected cells.

A Traunecker, A Lanzavecchia, K Karjalainen - The EMBO Journal, 1991 - embopress.org
The human immunodeficiency virus type 1 (HIV‐1) uses cell surface CD4 as a receptor to
infect susceptible cells. Therefore, different forms of soluble CD4 (sCD4) molecules have …

Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding.

QJ Sattentau, JP Moore - The Journal of experimental medicine, 1991 - rupress.org
The human immunodeficiency virus (HIV) binds to the surface of T lymphocytes and other
cells of the immune system via a high affinity interaction between CD4 and the HIV outer …

Cloning of the mouse hepatitis virus (MHV) receptor: expression in human and hamster cell lines confers susceptibility to MHV

GS Dveksler, MN Pensiero, CB Cardellichio… - Journal of …, 1991 - Am Soc Microbiol
The cellular receptor for murine coronavirus mouse hepatitis virus (MHV)-A59 is a member
of the carcinoembryonic antigen (CEA) family of glycoproteins in the immunoglobulin …

Inhibition of entry of HIV-1 in neural cell lines by antibodies against galactosyl ceramide

JM Harouse, S Bhat, SL Spitalnik, M Laughlin… - Science, 1991 - science.org
Although the CD4 molecule is the principal cellular receptor for the human
immunodeficiency virus (HIV), several CD4-negative cell lines are susceptible to infection …

HIV-associated nephropathy in transgenic mice expressing HIV-1 genes

P Dickie, J Felser, M Eckhaus, J Bryant, J Silver… - Virology, 1991 - Elsevier
Transgenic mice were produced that bore copies of a defective HIV provirus. The transgenic
offspring from three independently derived mouse lines manifested renal disease …

Human immunodeficiency virus type 1 gp120 envelope glycoprotein regions important for association with the gp41 transmembrane glycoprotein

E Helseth, U Olshevsky, C Furman… - Journal of virology, 1991 - Am Soc Microbiol
Insertion of four amino acids into various locations within the amino-terminal halves of the
human immunodeficiency virus type 1 gp120 or gp41 envelope glycoprotein disrupts the …