Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice

SGN Grant, TJ O'dell, KA Karl, PL Stein, P Soriano… - Science, 1992 - science.org
Mice with mutations in four nonreceptor tyrosine kinase genes, fyn, src, yes, and abl, were
used to study the role of these kinases in long-term potentiation (LTP) and in the relation of …

Double dissociation of fornix and caudate nucleus lesions on acquisition of two water maze tasks: further evidence for multiple memory systems.

MG Packard, JL McGaugh - Behavioral neuroscience, 1992 - psycnet.apa.org
The present study examined the effect of lesions of the caudate nucleus or fimbria–fornix on
the acquisition of two water maze tasks. In both tasks, two rubber balls with different visual …

A new one-trial test for neurobiological studies of memory in rats. III. Spatial vs. non-spatial working memory

A Ennaceur, K Meliani - Behavioural brain research, 1992 - Elsevier
Rats were submitted to object and spatial recognition tests (both based on the same
paradigm) and to the radial-arm maze. The results are as follows:(1) rats could discriminate …

Testosterone improves maze performance and induces development of a male hippocampus in females

RL Roof, MD Havens - Brain research, 1992 - Elsevier
In a combined behavioral and morphometric study, we observed a testosterone-related
sexual dimorphism in the granule cell layer of the hippocampus of Sprague-Dawley rats that …

Evolution of sex difference in spatial ability

SJC Gaulin - American Journal of Physical Anthropology, 1992 - Wiley Online Library
Many sex differences are likely to be adaptive consequences of sexual selection. Sex
differences in spatial ability are well described for Homo sapiens and laboratory rodents …

Lesions of the rat postsubiculum impair performance on spatial tasks

JS Taube, JP Kesslak, CW Cotman - Behavioral and neural biology, 1992 - Elsevier
Previous studies have identified a population of neurons in the postsubiculum that discharge
as a function of the rat's head direction in the horizontal plane (Taube, Muller, & Ranck …

Protective effects of brain hypothermia on behavior and histopathology following global cerebral ischemia in rats

EJ Green, WD Dietrich, F Van Dijk, R Busto… - Brain research, 1992 - Elsevier
The present experiments were designed to assess whether brain hypothermia can reduce
the behavioral and histopathological deficits associated with global forebrain ischemia …

Dissociation of spatial navigation and visual guidance performance in Purkinje cell degeneration (pcd) mutant mice

CR Goodlett, KM Hamre, JR West - Behavioural brain research, 1992 - Elsevier
Spatial learning in rodents requires normal functioning of hippocampal and cortical
structures. Recent data suggest that the cerebellum may also be esential. Neurological …

Short forms of the “reference-” and “working-memory” Morris water maze for assessing age-related deficits

MD Lindner, AH Balch, CP Vandermaelen - Behavioral and neural biology, 1992 - Elsevier
Short forms of the reference-and working-memory versions of the Morris water maze, each
limited to 10 trials, were examined for their reliability and sensitivity to age related deficits in …

Hippocampal cholinergic alterations and related behavioral deficits after early exposure to phenobarbital

Y Rogel-Fuchs, ME Newman, D Trombka… - Brain research …, 1992 - Elsevier
Mice were exposed to phenobarbital (PhB) prenatally and neonatally. Prenatal exposure
was accomplished by feeding the mother PhB (3 g/kg milled food) on gestation days 9–18 …