THE mammalian shc gene encodes two overlapping, widely expressed proteins of 46 and
52K, with a carboxy-terminal SH2 domain that binds activated growth factor receptors, and a …

IN the yeast Sacchromyces cerevisiae, addition of glucose to starved cells triggers a
transient rise in the intracellular level of cyclic AMP that induces a protein phosphorylation …

In Saccharomyces cerevisiae, the product of the CDC25 gene is an essential Ras activator
that appears to function by stimulating guanine nucleotide exchange on Ras. Using the …

GDP-dissociation stimulators (GDSs) are the key element for the regeneration of the active
state of ras proteins, but despite intensive investigations, little is so far known about their …

Mammalian ras genes substitute for the yeast RAS gene, and their products activate
adenylate cyclase in yeast cells, although the direct target protein of mammalian ras p21s …

Looks at research into growth-signalling mechanisms in eukaryotic cells that focuses on the
proteins encoded by the rasoncogene family. Report by Shou, et al in the July 23, 1992 …

The less abundant subunit of the asialoglycoprotein receptor, H2, may be encoded by at
least four variant transcripts as a result of alternative mRNA splicing. We had cloned two H2 …

The ras genes were first discovered as retroviral oncogenes and have subsequently been
found to be activated in some 30% of human tumours. The proteins that they encode are key …

RESEARCH NEWS ing features. For one thing, Feig says, one segment of the exchange
protein encoded by the gene turns out to have an unexpected resemblance to a sequence …