The catalytic subunit of cAMP-dependent protein kinase contains two stable phosphorylation
sites, Thr-197 and Ser-338 (Shoji, S., Titani, K., Demaille, JG, and Fischer, EH (1979) J. Biol …

cAMP-dependent protein kinase mediates a variety of cellular responses in most eukaryotic
cells. Many of these responses are cytoplasmic, whereas others appear to require nuclear …

1. Sodium absorption is the dominant ion transport process in conducting airways and is a
major factor regulating the composition of airway surface liquid. However, little is known …

The crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed
with an inhibitor peptide is reviewed. This structure defines the active site of the enzyme and …

Cyclic nucleotides were discovered about 30 years ago, becoming the prototype
intracellular messengers (Robison et al., 1971). Intracellular messenger signaling systems …

An inhibitor protein of the catalytic subunit of the cyclic 3′, 5′-AMP-dependent protein
kinase from the nematode Ascaris suum was isolated and characterized. The molecular …

Signaling pathways that convert extracellular stimuli into intracellular responses regulate
many diverse physiological and biochemical processes, and share many characteristics. An …

This study investigated the properties of the protein histidine kinase purified from yeast
Saccharomyces cerevisiae. Histone H4 from calf thymus was found to be the only good in …

Protein kinases are usually identified and characterized by radioisotopic assay. The
functional activity and substrates can, however, be also analyzed by a coupled enzymatic …