CTLA-4 and CD28: similar proteins, neighbouring genes.
C Balzano, N Buonavista, E Rouvier… - International journal of …, 1992 - europepmc.org
Subtractive cloning and screening yielded a cDNA clone corresponding to a molecule
expressed in activated T cells, called CTLA-4. At the protein level, CTLA-4, a single-V …
expressed in activated T cells, called CTLA-4. At the protein level, CTLA-4, a single-V …
Development of humanized bispecific antibodies reactive with cytotoxic lymphocytes and tumor cells overexpressing the HER2 protooncogene.
MR Shalaby, HM Shepard, L Presta… - The Journal of …, 1992 - rupress.org
The HER2 protooncogene encodes a 185-kD transmembrane phosphoglycoproteins,
human epidermal growth factor receptor 2 (p185HER2), whose amplified expression on the …
human epidermal growth factor receptor 2 (p185HER2), whose amplified expression on the …
Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A
JW Shiver, L Su, PA Henkart - Cell, 1992 - cell.com
The noncytotoxic rat mast cell tumor line RBL was transfected with genes for the cytotoxic
lymphocyte granule proteins cytolysin (perform) and granzyme A, giving transfectants with …
lymphocyte granule proteins cytolysin (perform) and granzyme A, giving transfectants with …
Retargeting of human lymphocytes against human ovarian carcinoma cells by bispecific antibodies: from laboratory to clinic
D Mezzanzanica, S Canevari, MI Colnaghi - International Journal of …, 1992 - Springer
We have selected a monoclonal antibody (MOv18) reactive with ovarian carcinoma, which
exhibits a restricted tumor specificity, a high affinity constant and which recognizes a 38-kDa …
exhibits a restricted tumor specificity, a high affinity constant and which recognizes a 38-kDa …
Engineering a humanized bispecific F (ab') 2 fragment for improved binding to T cells
ML Rodrigues, MR Shalaby… - … journal of cancer …, 1992 - pubmed.ncbi.nlm.nih.gov
We recently constructed a humanized bispecific antibody (BsF (ab') 2v1) by separate E. coli
expression of each Fab'arm followed by directed chemical coupling in vitro. BsF (ab') 2 v1 …
expression of each Fab'arm followed by directed chemical coupling in vitro. BsF (ab') 2 v1 …
Killing of human leukaemia/lymphoma B cells by activated cytotoxic T lymphocytes in the presence of a bispecific monoclonal antibody (αCD3/αCD19)
IA Haagen, R Van De Griend, M Clark… - Clinical & …, 1992 - Wiley Online Library
Bispecific antibodies (BsAb) can be used to retarget T cells irrespective of their specificity to
certain target cells inducing target cell lysis. We have tested the efficacy of the BsAb SHR‐1 …
certain target cells inducing target cell lysis. We have tested the efficacy of the BsAb SHR‐1 …
Human C‐ERBB‐2 proto‐oncogene product as a target for bispecific‐antibody‐directed adoptive tumor immunotherapy
T Nishimura, Y Nakamura, H Tsukamoto… - … journal of cancer, 1992 - Wiley Online Library
To develop an efficient strategy for the targeting of anti‐tumor effector cells, we prepared
bispecific antibody (BsAb) containing anti‐CD3 and an anti‐c‐erbB‐2 proto‐oncogene …
bispecific antibody (BsAb) containing anti‐CD3 and an anti‐c‐erbB‐2 proto‐oncogene …
Function associated molecules on nonspecific cytotoxic cells: role in calcium signaling, redirected lysis, and modulation of cytotoxicity
DL Evans, DT Harris, L Jaso-Friedmann - Developmental & Comparative …, 1992 - Elsevier
Monoclonal antibodies (mAbs) specific for a putative antigen receptor (function associated
molecule, FAM) on fish NCC were tested for their ability to initiate signal transduction …
molecule, FAM) on fish NCC were tested for their ability to initiate signal transduction …
Targeting of anti-tumor responses with bispecific antibodies
DM Segal, JH Qian, D Mezzanzanica, MA Garrido… - Immunobiology, 1992 - Elsevier
T cells can be induced to specifically lyse tumor cells with bispecific antibodies containing
anti-T cell receptor mAbs crosslinked to anti-tumor mAbs. Such «targeted cytolysis» requires …
anti-T cell receptor mAbs crosslinked to anti-tumor mAbs. Such «targeted cytolysis» requires …
Poly-(ADP-ribose) polymerase partially contributes to target cell death triggered by cytolytic T lymphocytes.
FA Redegeld, S Chatterjee, NA Berger… - Journal of immunology …, 1992 - journals.aai.org
We hypothesized that CTL-induced target cell (TC) death is partially due to processes that
follow the DNA damage in target cells and include the activation of poly-ADP-ribose …
follow the DNA damage in target cells and include the activation of poly-ADP-ribose …