Repetitive, episodic hypoxia causes diurnal elevation of blood pressure in rats.

EC Fletcher, J Lesske, W Qian, CC Miller 3rd… - Hypertension, 1992 - Am Heart Assoc
An association between chronic high blood pressure and obstructive sleep apnea has been
described. We hypothesized that repetitive episodic hypoxia patterned after the hypoxia …

Sympathetic denervation blocks blood pressure elevation in episodic hypoxia.

EC Fletcher, J Lesske, J Culman, CC Miller… - Hypertension, 1992 - Am Heart Assoc
We have previously described a rat model that responds to repetitive episodic hypoxia (FiO2
nadir 3-5% for 12 seconds every 30 seconds for 7 hr/day for 35 days) with chronic increase …