Cells of higher vertebrates have evolved mechanisms that allow a sample of their
intracellular contents to be available for surveillance by the immune system. This display of …

Publisher Summary This chapter discusses the eradication of tumor by adoptive transfer of
cytotoxic T lymphocytes. Complete and permanent eradication of tumors by …

The transporter associated with the antigen processing 1 (TAP1) gene encodes a subunit for
a transporter, presumed to be involved in the delivery of peptides across the endoplasmic …

In response to heavy metal stress, plants and certain fungi, such as the fission yeast
Schizosaccharomyces pombe, synthesize small metal‐binding peptides known as …

THE mutant human cell line T2 is defective in antigen presentation in the context of class I
major histocompatibility complex (MHC) molecules1, 2 and also in that transfected T2 cells …

We have produced the human class II histocompatibility protein, HLA-DR1, as a soluble,
secreted glycoprotein in insect cells infected with baculoviruses carrying truncated α and β …

MAJOR histocompatibility complex (MHC) class I molecules present peptides derived from
the endogenous protein pool to cytotoxic T lymphocytes, which can thus recognize …

Using immunoblotting techniques we studied the sera from small cell lung cancer and non-
small cell lung cancer patients for antibodies directed against p53. We have also …

Publisher Summary This chapter presents an overview of T cell recognition and function.
Complex organisms coevolved with a wide variety of microorganisms—viruses, bacteria …

The WHO Nomenclature Committee for factors of the HLA system met in Hakone after the 1
lth International Histocompatibility Workshop and Conference during November 1991 to …