Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease
CT Guy, RD Cardiff, WJ Muller - Molecular and cellular biology, 1992 - Taylor & Francis
The effect of mammary gland-specific expression of the polyomavirus middle T antigen was
examined by establishing lines of transgenic mice that carry the middle T oncogene under …
examined by establishing lines of transgenic mice that carry the middle T oncogene under …
[HTML][HTML] Complete deficiency of plasminogen-activator inhibitor type 1 due to a frame-shift mutation
WP Fay, AD Shapiro, JL Shih, RR Schleef… - New England Journal …, 1992 - Mass Medical Soc
THE process of plasminogen activation is considered a critical component of diverse
biologic systems in humans. This reaction, which is catalyzed in vivo by tissue-type and …
biologic systems in humans. This reaction, which is catalyzed in vivo by tissue-type and …
In vitro model of angiogenesis using a human endothelium‐derived permanent cell line: contributions of induced gene expression, G‐proteins, and integrins
J Bauer, M Margolis, C Schreiner… - Journal of cellular …, 1992 - Wiley Online Library
The EA hy926 cell line is a continuous, clonable, human cell line that displays a number of
features characteristic of vascular endothelial cells (Edgell et al., 1983). Here we report that …
features characteristic of vascular endothelial cells (Edgell et al., 1983). Here we report that …
c-ets1 proto-oncogene is a transcription factor expressed in endothelial cells during tumor vascularization and other forms of angiogenesis in humans.
N Wernert, MB Raes, P Lassalle… - The American journal …, 1992 - ncbi.nlm.nih.gov
The c-ets1 proteins are transcriptional activators expressed within endothelial cells during
blood vessel development in chick embryos. The authors show by in situ hybridization that c …
blood vessel development in chick embryos. The authors show by in situ hybridization that c …
Basic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activity.
R Flaumenhaft, M Abe, P Mignatti… - The Journal of cell biology, 1992 - rupress.org
Exposure of bovine aortic or capillary endothelial cells to basic FGF (bFGF) for 1 h resulted
in an approximately sixfold increase in plasminogen activator (PA) activity by 18 h that …
in an approximately sixfold increase in plasminogen activator (PA) activity by 18 h that …
In vivo patterns of expression of urokinase and its inhibitor PAI-1 suggest a concerted role in regulating physiological angiogenesis.
E Bacharach, A Itin, E Keshet - Proceedings of the National …, 1992 - National Acad Sciences
To evaluate the role of plasminogen activators (PAs) in physiological angiogenesis, we have
investigated the in vivo patterns of expression of urokinase-type PA (uPA) and PA-inhibitor …
investigated the in vivo patterns of expression of urokinase-type PA (uPA) and PA-inhibitor …
[HTML][HTML] Regulation of gene expression by SPARC during angiogenesis in vitro. Changes in fibronectin, thrombospondin-1, and plasminogen activator inhibitor-1.
TF Lane, ML Iruela-Arispe, EH Sage - Journal of Biological Chemistry, 1992 - Elsevier
Angiogenesis in vitro, the formation of capillary-like structures by cultured endothelial cells,
is associated with changes in the expression of several extracellular matrix proteins. The …
is associated with changes in the expression of several extracellular matrix proteins. The …
Plasminogen activator inhibitor‐1 is induced in migrating endothelial cells
MS Pepper, AP Sappino, R Montesano… - Journal of cellular …, 1992 - Wiley Online Library
It has been proposed that a finely tuned protease-anti-protease equilibrium must be mainted
during process of cell migration in order to limit extracellular proteolysis to the close proxmity …
during process of cell migration in order to limit extracellular proteolysis to the close proxmity …
Fibrinolytic mechanisms in tumor growth and spreading
T Südhoff, W Schneider - The clinical investigator, 1992 - Springer
The high prevalence of hypercoagulative states in cancer patients has been known for more
than a century. Venous thrombosis in gastric cancer was described by Trousseau in 1865 …
than a century. Venous thrombosis in gastric cancer was described by Trousseau in 1865 …
Targeted disruption of the tissue inhibitor of metalloproteinases gene increases the invasive behavior of primitive mesenchymal cells derived from embryonic stem …
CM Alexander, Z Werb - The Journal of cell biology, 1992 - rupress.org
The metalloproteinase family of proteolytic enzymes can degrade extracellular matrix and
facilitate invasive migration. This class of enzymes is specifically inhibited by the tissue …
facilitate invasive migration. This class of enzymes is specifically inhibited by the tissue …