Objective To review recent studies on the development of new tests of human sperm
function and evaluation of which sperm characteristics are most important for fertilization in …

Perspectives Page 1 Perspectives Biology of Mammalian Fertilization: Role of the Zona
Pellucida Jurrien Dean Laboratory ofCellular and Developmental Biology, National Institute …

DESPITE its importance, the molecular basis of mammalian gamete recognition has
remained unclear. The enzyme β-1, 4-galactosyltransferase (Gal-transferase) has been …

We tested the effect of extracellular adenosine 5'-triphosphate (ATPo) on the activation of
human spermatozoa. ATPo, in a concentration range from 50 microM to 5 mM, induced the …

Complementary adhesion molecules are located on the surface of mouse eggs and sperm.
These molecules support species-specific interactions between sperm and eggs that lead to …

The ability of mouse zona pellucida glycoprotein ZP3 (mZP3) to function as a sperm receptor
is attributable to certain of its oligosaccharides, not to its polypeptide (PM Wassarman, 1990 …

Zona pellucida (ZP)-induced acrosomal exocytosis in mammalian spermatozoa is thought to
be mediated by signal transduction cascades similar to those found in hormonally …

Objective To determine the optimal conditions to obtain live acrosome-reacted spermatozoa
for micromanipulation. Design Design Experiments were performed to determine time and …

Mammalian sperm acrosomes contain a trypsinlike protease called acrosin which causes
limited and specific hydrolysis of the extracellular matrix of the mammalian egg, the zona …

The acrosome reaction induced by the zona pellucida in mouse sperm has been shown to
proceed in two stages experimentally distinguishable by the fluorescent probe …