Although a bewildering array of cell surface carbohydrate structures have been described,
the physiological relevance of any of these complex molecules has often eluded biologists …

The lymphoid system is functionally compartmentalized in vivo into discrete primary,
secondary, and tertiary lymphoid organs. Primary lymphoid tissues--the bone marrow and …

T cell costimulation by molecules on the antigen presenting cell (APC) is required for optimal
T cell proliferation. The B7 molecule on APC binds the T lymphocyte receptor CD28 …

The receptor-mediated adhesion of cells to ligand-coated surfaces in viscous shear flow is
an important step in many physiological processes, such as the neutrophil-mediated …

P-selectin (CD62, GMP-140, PADGEM), a Ca (2+)-dependent lectin on activated platelets
and endothelium, functions as a receptor for myeloid cells by interacting with sialylated …

In this article Antal Rot calls into question the generally accepted notion that gradients of
soluble chemotactic factors are responsible for leukocyte emigration from the circulation into …

Leucocytes travel around the body in the blood vessels but, with the exception of platelets,
must normally leave the bloodstream to exert their protective influence in the neighbouring …

Adhesion of lymphocytes to endothelium is vital to lymphocyte migration into lymphoid tissue
and into inflammatory sites. In this review, Yoji Shimizu and colleagues identify the …

E-selectin (ELAM-1) and P-selectin (GMP-140, PADGEM, CD62) have both been described
as human endothelial cell adhesion molecules for neutrophils and monocytes. Cell surface …

Rapid translocation of P-selectin (GMP-140) from cytoplasmic granules to the cell
membrane of endothelial cells promotes adhesive interactions with neutrophils which, when …