The application of computer simulation to molecular systems of biochemical interest is
reviewed. It is shown that computer simulation is a tool complementary to experimental …

A human cDNA was cloned that encodes a DNA-binding protein (SATBl) that is expressed
predominantly in thymus and binds selectively to the nuclear matrix/scaffold-associating …

Strand-symmetric relative abundance functionals for di-, tri-, and tetranucleotides are
introduced and applied to sequences encompassing a broad phylogenetic range to discern …

Novel DNA-binding proteins, especially repressors of gene expression, are obtained by
variegation of genes encoding known binding protein and selection for proteins binding the …

The crystal structure of the DNA repair enzyme endonuclease III, which recognizes and
cleaves DNA at damaged bases, has been solved to 2.0 angstrom resolution with an R …

The crystal structure of the λ repressor—operator complex has been refined to an R-factor of
18.9% at 1.8 Å resolution. This refinement, using data collected at low temperature, has …

The dominant transcriptional regulator of the papiIlomaviruses, E2, binds to its specific DNA
target through a previously unobserved dimeric ant i para I lei β-barrel. The DNA is severely …

The three-dimensional structure of BirA, the repressor of the Escherichia coli biotin
biosynthetic operon, has been determined by x-ray crystallography and refined to a …

The crystal structure of the met represser–operator complex shows two dimeric repressor
molecules bound to adjacent sites 8 base pairs apart on an 18-base-pair DNA fragment …

To characterize water binding to proteins, which is fundamental to protein folding, stability
and activity, the relationships of 10,837 bound water positions to protein surface shape and …