Ca2+ regulation of mechanical properties of striated muscle. Mechanistic studies using extraction and replacement of regulatory proteins.

RL Moss - Circulation research, 1992 - Am Heart Assoc
Extraction of regulatory proteins from thick and thin filaments of vertebrate striated muscle
has proven to be an important approach in elucidating roles of these proteins in regulating …

Molecular mechanism of troponin-C function

Z Grabarek, T Tao, J Gergely - Journal of Muscle Research & Cell Motility, 1992 - Springer
Conclusions There is now a large body of evidence in support of the view that Ca 2+ binding
to the low affinity sites of TnC induces a movement of helices B and C away from helices A …

Mutation of the high affinity calcium binding sites in cardiac troponin C.

JC Negele, DG Dotson, W Liu, HL Sweeney… - Journal of Biological …, 1992 - ASBMB
Fast skeletal and cardiac troponin C (TnC) contain two high affinity Ca2+/Mg2+ binding sites
within the C-terminal domain that are thought to be important for association of TnC with the …