Drug craving, the desire to experience the effect (s) of a previously experienced
psychoactive substance, has been hypothesized to contribute significantly to continued drug …

Publisher Summary The limbic structures (nucleus accumbens, amygdala) as well as the
striatum receive afferents from the two main dopaminergic systems of the CNS (the …

Previous work using systemic injections of dopamine receptor antagonists has established
that dopamine D 1 receptors may have a role in cocaine self-administration. The purpose of …

The firing patterns of neurons in the nucleus accumbens (NA) were recorded in rats trained
to self-administer cocaine via response contingent intravenous drug infusions. Recordings …

Heroin self-administration behavior under a progressive ratio (PR) schedule of
reinforcement was evaluated in rats. The schedule was designed to restrict drug intake …

Animals were trained to traverse a straight alley for drug reinforcement consisting of five IV
injections of either 0.75 mg/kg/injection cocaine (n= 6) or 0.06 mg/kg/injection heroin (n= 6) …

Drugs of abuse putatively exert their rewarding actions by activating specific mechanisms in
the brain. Sensitivity of these mechanisms to stimulation by drugs may be a factor in the …

Intracranial Cocaine Self-Administration into the Medial Prefrontal Cortex Increases Dopamine
Turnover in the Nucleus Accumbens1 Page 1 0022-3565/93/2652-0692$03.00/0 THE Jowissi OF …

Daily, intermittent, subcutaneous cocaine injections produce sensitization, while the
continuous administration of cocaine produces tolerance to the behavioral effects of …

1 The effects of the 5‐HT3 receptor antagonists, ondansetron and tropisetron, on morphine
consumption were studied in naive and morphine‐dependent rats. 2 The administration of …