Controlled release devices, based on high molecular weight hydrophilic polymers, have
been shown in studies in dogs to have extended gastric retentive properties. However, the …

The ability of high viscosity hydroxypropylmethylcellulose (HPMC) to reduce postprandial
glucose concentrations was assessed in patients with non-insulin-dependent diabetes …

Didanosine is a purine nucleoside analogue approved for the treatment of human
immunodeficiency virus infection. It is extremely unstable at pH values less than 3 and …

The bioavailability and pharmacokinetic properties of two sustained-release (SR)
formulations of chlorphenesin carbamate (CPC) with different in vitro release rates were …

Metoprolol, a β 1-adrenergic blocker, was formulated into a number of sustained-release
formulations. Some of these were prepared by a spray-drying technique specially developed …

Double peaks in the plasma concentration-time profile after oral administration have been
reported for several compounds. A pharmacokinetic model incorporating discontinuous GI …