Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions

E Moser, MB Moser, P Andersen - Journal of neuroscience, 1993 - Soc Neuroscience
The hippocampus plays an essential role in spatial learning. To investigate whether the
whole structure is equally important, we compared the effects of variously sized and …

A triple dissociation of memory systems: hippocampus, amygdala, and dorsal striatum.

RJ McDonald, NM White - Behavioral neuroscience, 1993 - psycnet.apa.org
This study investigated the respective roles of the hippocampus, the amygdala, and the
dorsal striatum in learning and memory. A standard set of experimental conditions for …

Age-dependent cognitive and behavioral deficits after kainic acid seizures.

CE Stafstrom, A Chronopoulos, S Thurber… - Epilepsia, 1993 - europepmc.org
The long-term behavioral and cognitive effects of seizures at different ages were studied
using the kainic acid (KA) seizure model. Rats of postnatal (P) ages (in days) 5, 10, 20, 30 …

Posterior cingulate cortex and spatial memory: A microlimnology analysis

RJ Sutherland, JM Hoesing - Neurobiology of cingulate cortex and limbic …, 1993 - Springer
The neurobiology of cingulate cortex is like a dog. Each of the four areas of study—anatomy,
physiology, chemistry, and behavior—forms one of the dog's legs. No one notices it when …

The dentate gyrus is sexually dimorphic in prepubescent rats: testosterone plays a significant role

RL Roof - Brain research, 1993 - Elsevier
In a morphological examination of the hippocampal formation of pre-pubescent rats, a
testosterone-related sexual dimorphism was observed. The dentate gyrus granule cell layer …

Place navigation in rats with unilateral tetrodotoxin inactivation of the dorsal hippocampus: place but not procedural learning can be lateralized to one hippocampus.

AA Fenton, J Bures - Behavioral neuroscience, 1993 - psycnet.apa.org
Lateralization of the Morris water maze task was examined by injecting 5 ng of tetrodotoxin
(TTX) into 1 dorsal hippocampus (HPC) of chronically cannulated rats (n= 20). The task …

Selective loss of hippocampal granule cells following adrenalectomy: implications for spatial memory

CD Conrad, EJ Roy - Journal of Neuroscience, 1993 - Soc Neuroscience
We examined the effects of long-term adrenalectomy (ADX) on hippocampal anatomy and
behavioral learning in two spatial memory tasks. We assessed damage throughout the …

Possible anatomical basis of recovery of function after neonatal frontal lesions in rats.

B Kolb, R Gibb - Behavioral neuroscience, 1993 - psycnet.apa.org
Rats given medial frontal lesions on Postnatal Day 1 or Day 10 were trained on the Morris
water task on Days 19–21 or Days 56–58. The operated groups were equally impaired at …

An examination of the relations between hippocampal long‐term potentiation, kindling, afterdischarge, and place learning in the water maze

DP Cain, EL Hargreaves, F Boon, Z Dennison - Hippocampus, 1993 - Wiley Online Library
Two approaches were used to study the relations between the acquisition of place learning
in the Morris water maze and long‐term potentiation (LTP), kindling, and afterdischarge …

Acetyl-L-carnitine: behavioral, electrophysiological, and neurochemical effects

S Davis, AL Markowska, GL Wenk, CA Barnes - Neurobiology of aging, 1993 - Elsevier
—Aged rats were chronically administered acetyl-l-carnitine (AC) for 10 months. During this
period they were tested on learning and sensorimotor tasks and were then subsequently …