I. Introduction U NTIL recently, there has been little scientific inquiry into the physiological
significance of, and possible therapy for, GH deficiency in adulthood. This was because the …

Detailed studies of the ontogeny of growth hormone (GH) secretion have shown
unequivocally that GH is produced throughout life but secretion declines progressively to …

To determine whether testosterone modulates the somatotropic axis in adult males, we
compared 24-h GH secretion (from 20-min sampling, using Cluster analysis) and insulin-like …

OBJECTIVE Insulin like growth factor‐I (IGF‐I) levels in post‐menopausal women are
reduced by oral administration of the synthetic oestrogen ethinyl oestradiol but increased by …

In postmenopausal women oral ethinylestradiol causes a reduction in circulating insulin-like
growth factor 1 (IGF-1) and an increase in serum growth hormone levels. There are no data …

The significance of growth hormone in the physiology of bone remodelling is now strongly
recognized. It influences osteoblast function and growth in vitro as well as in vivo. Although …

Growth hormone (GH) is an important metabolic hormone, which stimulates net protein
anabolism, lipolysis, and linear bone growth. Pulses of GH secretion arise from interactions …

Bone tissue is a source of growth factors; among them, insulin-like growth factor I (IGF-I) is
probably an important local regulator of bone formation. This study has been carried out in …

The treatment of postmenopausal symptoms was studied in 26 healthy women using a new
synthetic rubber (Kraton D 2109) vaginal ring containing 53 mg of 17β-oestradiol. All women …

Serial IGF-1 levels in patients prior to and during adjuvant tamoxifen (TAM) treatment were
followed in a retrospective study. Serum IGF-1 levels were determined by …