GTPases of the Ras superfamily regulate many aspects of cell growth, differentiation and
action. Their functions depend on their ability to alternate between inactive and active forms …

From the multitude of mutations that have been tested in p21ras, a common theme emerges
regarding its interaction with the effector target, GAPs, and the newly discovered exchange …

Antisera against murine Son of sevenless (SOS) recognize a protein of M, 155,000 in rat-l
fibroblasts with specific guanine nucleotide exchange activity toward p2+ i& “sm Epidermal …

A human complementary DNA was isolated that encodes a widely expressed protein,
hSos1, that is closely related to Sos, the product of the Drosophila son of sevenless gene …

BCR-ABL is a chimeric oncoprotein that exhibits deregulated tyrosine kinase activity and is
implicated in the pathogenesis of Philadelphia chromosome (Ph 1)-positive human …

Hepatocyte growth factor/scatter factor (HGF/SF) induces mitogenesis and cell dissociation
upon binding to the protein-tyrosine kinase receptor encoded by the MET proto-oncogene …

Signal transmission by insulin involves tyrosine phosphorylation of a major insulin receptor
substrate (IRS-1) and exchange of Ras-bound guanosine diphosphate for guanosine …

The Saccharomyces cerevisiae CDC25 gene and closely homologous genes in other
eukaryotes encode guanine nucleotide exchange factors for Ras proteins. We have …

ras‐related GTPases participate in signaling for a variety of cellular processes. The
GTPases cycle between a GTP‐bound active state and a GDP‐bound inactive state. This …

The hematopoietically expressed product of the vav proto-oncogene, Vav, shares homology
with guanine nucleotide releasing factors (GRFs)[also called guanosine diphosphate …