A reaction between enzyme renin and its only natural substrate angiotensinogen is the initial
and rate-limiting step for producing a potent vasoconstrictor angiotensin II as the final …

Steps toward molecular cardiovascular therapy.(Left) Coronary atherosclerotic lesion in
apolipoprotein E-deficient mice.(Center) Therapeutic targets in the renin-angiotensin …

Our understanding of cardiovascular regulation has advanced primarily through the
pharmacological, surgical, and/or physiological manipulation of whole animal models …

Over the past decade, the development of gene-transfer technology in whole animals has
afforded unprecedented opportunities for investigators to probe complex regulatory systems …

We established an efficient and nontoxic in vivo gene transfer method mediated by the
Sendai virus (hemagglutinating virus of Japan [HVJ]), liposomes, and nuclear protein. In this …

1. Animal studies have implicated the angiotensin-converting enzyme (ACE) gene as an
inherited risk factor contributing towards elevation of blood pressure. 2. A polymorphism of …

Recent linkage studies in segregating populations derived from crosses of genetically
hypertensive rats and normotensive rats have identified several chromosome regions that …

The endocrine system is a complex and well-organized mechanism by which body
homeostasis is maintained. Infact, peptide or protein hormones play important roles in the …

One of the important problems of neurobiology concerns the mechanisms underlying the
ability of the nervous system to respond to external stimuli, such as hormones and growth …

1. Biochemical properties of human renin expressed in transgenic mice (hRN8-12 mice)
carrying the human renin gene (Fukamizu et al. Biochem Biophys Res Commun 1989; 165 …