The cyclin-dependent kinase CdkP associates with cyclins A, D, and E and has been
implicated in the control of the Gl to S phase transition in mammals. To identify potential …

A cascade of events is triggered upon the addition of growth factor to quiescent mammalian
cells, which ultimately restarts proliferation by inducing the transition from G0/G1 to S-phase …

The key cell-cycle regulator Cdc2 belongs to a family of cyclin-dependent kinases in higher
eukaryotes. Dominant-negative mutations were used to address the requirement for kinases …

Abstract Cyclin-dependent kinase 2 (CDK2) is a member of a highly conserved family of
protein klnases that regulate the eukaryotic cell cycle. The crystal structures of the human …

We used the interaction trap, a yeast genetic selection for interacting proteins, to isolate
human cyclin-dependent kinase interactor 1 (Cdi1). In yeast, Cdi1 interacts with cyclin …

Mammalian D-type cyclins are growth factor-regulated, delayed early response genes that
are presumed to control progression through the G1 phase of the cell cycle by governing the …

The major events of the cell division cycle are triggered by periodic changes in the activity of
cyclin-dependent protein kinases (CDKs). In mammals, the members of the CDK family …

ABSTRACT Cyclin-dependent kinase 5 (cdk5) was originally isolated on the basis of its
close primary sequence homology to the human cdc2 serine/threonine kinase, the prototype …

Summary Transforming growth factor (31 (TGFgl) causes Gl growth arrest and the
accumulation of unphosphorylated retinoblastoma protein (Fib) in responsive cells. Cdk4 …

DNA replication in mammalian cells occurs in discrete nuclear foci. Here we show that
terminally dlfferentiated myotubes can be induced to reenter S phase and show the same …