Publisher Summary This chapter discusses the historical background of interleukin-1 (IL-1)
inhibitors and the experimental work that led to the initial identification of the molecule …

Bacterial meningitis remains a disease with associated unacceptable morbidity and mortality
rates despite the availability of effective bactericidal antimicrobial therapy. Through the use …

The cause of acquired immunodeficiency syndrome (AIDS) dementia, which is a frequent
late manifestation of human immunodeficiency virus (HIV) infection, is unknown but …

Fig. I. Proposed terminology of the septic process (systemic inflammatory response
syndrome) in children. In general, the risk of dying increases as one moves down the …

Bacterial collagenase causes hemorrhagic necrosis of brain. We studied the enzyme's effect
on blood-brain barrier (BBB) permeability and extracellular matrix (ECM) structure by …

Streptococcus suis was first associated with neonatal meningitis in pigs during the early
1960s, and in the early 1970s a similar condition caused by this species appeared in …

The killing of bacteria gaining access to the central nervous system is insufficient and
requires bactericidal antibiotics for treatment. The inefficient host response in cerebrospinal …

A soluble form of the intercellular adhesion molecule-(sICAM-1) was measured in paired
cerebrospinal fluid (CSF)/blood samples from 123 patients with differenr neurological …

Glucocorticoids are potent inhibitors of inflammation and endotoxic shock. This probably
occurs through an inhibition of the synthesis of pro‐inflammatory cytokines as well as of …

Injection of lipopolysaccharide (LPS) into rabbil knee joints provoked leucocyte infiltration
and loss of proteoglycan (PG) from the cartilage. We investigated the role of IL-1 and IL-1 …