How does HIV cause AIDS?

RA Weiss - Science, 1993 - science.org
Many questions have been posed about acquired immunodeficiency syndrome (AIDS)
pathogenesis. Is human immunodeficiency virus (HIV) both necessary and sufficient to …

Pathogenesis of human immunodeficiency virus infection

JA Levy - Microbiological reviews, 1993 - Am Soc Microbiol
The lentivirus human immunodeficiency virus (HIV) causes AIDS by interacting with a large
number of different cells in the body and escaping the host immune response against it. HIV …

A TH1→ TH2 switch is a critical step in the etiology of HIV infection

M Clerici, GM Shearer - Immunology today, 1993 - cell.com
This viewpoint proposes that an imbalance in the Tul-type and TH2-type responses
contributes to the immune dysregulation associated wiib HIV infection, and that resistance to …

Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding

M Thali, JP Moore, C Furman, M Charles… - Journal of …, 1993 - Am Soc Microbiol
Interaction with the CD4 receptor enhances the exposure on the human immunodeficiency
type 1 gp120 exterior envelope glycoprotein of conserved, conformation-dependent …

Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus

D Naniche, G Varior-Krishnan, F Cervoni… - Journal of …, 1993 - Am Soc Microbiol
A monoclonal antibody (MCI20. 6) which inhibited measles virus (MV) binding to host cells
was previously used to characterize a 57-to 67-kDa cell surface glycoprotein as a potential …

Gene inoculation generates immune responses against human immunodeficiency virus type 1.

B Wang, KE Ugen, V Srikantan… - Proceedings of the …, 1993 - National Acad Sciences
Recently, immunization techniques in which DNA constructs are introduced directly into
mammalian tissue in vivo have been developed. In theory, gene inoculation should result in …

Structure of a human rhinovirus complexed with its receptor molecule

NH Olson, PR Kolatkar, MA Oliveira, RH Cheng… - Regulation of Gene …, 1993 - Springer
Human rhinoviruses are one of the major causes of the common cold. They, like other
picornaviruses, are icosahedral assemblies of 60 protomers that envelope a single, positive …

Design, intracellular expression, and activity of a human anti-human immunodeficiency virus type 1 gp120 single-chain antibody.

WA Marasco, WA Haseltine… - Proceedings of the …, 1993 - National Acad Sciences
A single-chain antibody, derived from a human monoclonal antibody that recognizes the
CD4 binding region of the human immunodeficiency virus type 1 (HIV-1) envelope protein …

[HTML][HTML] Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant.

ED Anderson, L Thomas, JS Hayflick… - Journal of Biological …, 1993 - Elsevier
Furin is a membrane-associated calcium-dependent serine endoprotease that cleaves
proproteins on the carboxyl side of the consensus sequence-Arg-X-Lys/Arg-Arg-. Using site …

Cellular receptors and viral glycoproteins involved in retrovirus entry

RA Weiss - The retroviridae, 1993 - Springer
The initial steps in virus infection involve the binding of virions to specific cell surface
receptors. Following the attachment of enveloped viruses, further events lead to membrane …