Fetal alcohol syndrome: the vulnerability of the developing brain and possible mechanisms of damage

JR West, WJA Chen, NJ Pantazis - Metabolic brain disease, 1994 - Springer
Fetal alcohol exposure has multiple deleterious effects on brain development, and
represents a leading known cause of mental retardation. This review of the effects of alcohol …

Suppression of gene expression by homologous transgenes

C Cogoni, N Romano, G Macino - Antonie Van Leeuwenhoek, 1994 - Springer
When a wild-type strain of Neurospora crassa is transformed with different portions of the
carotenogenic albino 1 or albino 3 genes, up to 30–35% of the transformants show an …

Expression of DNA methyltransferase gene in mature and immature neurons as well as proliferating cells in mice

K Goto, M Numata, JI Komura, T Ono, TH Bestor… - Differentiation, 1994 - Elsevier
A major role of DNA-methyltransferase (MTase) is thought to be maintaining the DNA methyl-
ation profile through DNA replication. However, previous surveys of mRNA distribution in …

[HTML][HTML] Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human …

JF Costello, BW Futscher, K Tano, DM Graunke… - Journal of Biological …, 1994 - Elsevier
Expression of the O6-methylguanine DNA methyltransferase (MGMT) gene in human glioma
cell lines is strongly associated with resistance to the chemotherapeutic agent 1, 3-bis (2 …

Global DNA hypomethylation increases progressively in cervical dysplasia and carcinoma

YI Kim, A Giuliano, KD Hatch, A Schneider, MA Nour… - Cancer, 1994 - Wiley Online Library
Background. Global DNA hypomethylation has been observed in some human neoplasms
and has been implicated as an important factor in carcinogenesis. The current study was …

DNA methylation as an intermediate biomarker in colorectal cancer: modulation by folic acid supplementation

M Cravo, P Fidalgo, AD Pereira… - European Journal of …, 1994 - JSTOR
Several studies have suggested that DNA hypomethylation is an early step in colorectal
carcinogenesis. However, it is not clear at which stage in carcinogenesis this …

Rapid evolution of a heteroplasmic repetitive sequence in the mitochondrial DNA control region of carnivores

AR Hoelzel, JV Lopez, GA Dover, SJ O'Brien - Journal of molecular …, 1994 - Springer
We describe a repetitive DNA region at the 3′ end of the mitochondrial DNA (mtDNA)
control region and compare it in 21 carnivore species representing eight carnivore families …

Polyamines, DNA methylation, and fungal differentiation

J Ruiz-Herrera - Critical reviews in microbiology, 1994 - Taylor & Francis
Mucorales constitute a group of fungi that, because of their growth characteristics, have
been used extensively in the study of cell differentiation, cell morphogenesis, and stimuli …

DNA methylation properties: consequences for pharmacology

M Szyf - Trends in pharmacological sciences, 1994 - cell.com
The aim of pharmacology has traditionally been to develop compounds that could mimic,
activate or antagonize the molecules that control and regulate the physiological state of an …

DNA methylation from embryo to adult

A Razin, T Kafri - Progress in nucleic acid research and molecular …, 1994 - Elsevier
Publisher Summary This chapter discusses the deoxyribonucleic acid (DNA) methylation
from embryo to adult. The existence of tissue-specific methylation patterns and the results of …