The invention concerns pharmaceutically useful com pounds of the formula I, in which R, R2,
R3, R', Ra, Rb, A, X and Z have the various meanings defined herein, and their non-toxic …

Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic
moiety con taining one or two nitrogen atoms; A is (1-6C) alkylene,(3-6C) alkenylene,(3-6C) …

QR I Q-A1-x-Ar-c-R2 wherein Q is an optionally substituted 10-membered bicyclic
heterocyclic moiety containing 1 or 2N's and a further O or S heteroatom; Al is a direct link to …

R1 is hydrogen,(1-6C) alkyl,(3-6C) alkenyl,(3–6C Dalkynyl, cyano-(1-4C) alkyl or (2-4C)
alkanoyl, or optionally substituted benzoyl; and R2 and R3 together form a (3-6C) alkylene …

The invention concerns pharmaceutically useful com pounds of the formula I, in which Q, X,
Gl, Z and Ra have the various meanings defined herein, and their non-toxic salts, and …

Arlis phenyl or naphthyl, or a 10-membered bicyclic heterocyclic moiety containing one or
two nitro gen heteroatoms and optionally containing a fur ther heteroatom selected from …

Q is an optionally substituted 10-membered bicyclic heterocyclic moiety containing 1 or 2 N's
and a fur ther O or S heteroatom; A is a direct link to X1 or (1-3C) alkylene; X is oxy, thio …

X is oxy, thio, sulphinyl, sulphonyl or imino; Ar is phenylene which may optionally bear one
or two substituents or Ar is an optionally substituted 6-mem bered heterocyclene moiety …

R2 and R3 together form a group of the formula-A2-X2-A3-which, together with the carbon
atom to which A2 and A3 are attached, defines a ring having 5 to 7 ring atoms, wherein each …

R4 OX wherein R1 is hydrogen, or hydrocarbyl. R3 and R4 are independently, H, alkyl,
various functional groups or alkylenedioxy, X is phenylene optionally bearing a sub stituent …