Free radical adducts induce alterations in DNA cytosine methylation.

SA Weitzman, PW Turk… - Proceedings of the …, 1994 - National Acad Sciences
Methylation of cytosines in DNA is important for the regulation of expression of many genes.
During carcinogenesis, normal patterns of gene methylation can be altered. Oxygen radical …

Posttranscriptional silencing of reporter transgenes in tobacco correlates with DNA methylation.

I Ingelbrecht, H Van Houdt… - Proceedings of the …, 1994 - National Acad Sciences
Endogenous plant genes or transgenes can be silenced on introduction of homologous
gene sequences. Here we document a reporter gene-silencing event in Nicotiana tabacum …

Evidence that random and imprinted Xist expression is controlled by preemptive methylation

DP Norris, D Patel, GF Kay, GD Penny, N Brockdorff… - Cell, 1994 - cell.com
The mouse Xist gene is expressed exclusively from the inactive X chromosome and may
control the initiation of X tnactivatlon. We show that in somatic tissues the 5'end of the silent …

Homology-dependent gene silencing in transgenic plants: epistatic silencing loci contain multiple copies of methylated transgenes

AJM Matzke, F Neuhuber, YD Park, PF Ambros… - Molecular and General …, 1994 - Springer
Previous work has shown that two homologous, unlinked transgene loci can interact in plant
nuclei, leading to non-reciprocal trans-inactivation and methylation of genes at one locus …

Evidence for cytosine methylation of non‐symmetrical sequences in transgenic Petunia hybrida.

P Meyer, I Niedenhof, M Ten Lohuis - The EMBO journal, 1994 - embopress.org
A considerable proportion of cytosine residues in plants are methylated at carbon 5.
According to a well‐accepted rule, cytosine methylation is confined to symmetrical …

7 Mechanisms of Genomic Imprinting in Mammals

JD Cold, RA Pedersen - Current Topics in Developmental Biology, 1994 - Elsevier
Publisher Summary The evident specialization of maternal and paternal genomes in
mammals has been defined as genomic imprinting and is thought to arise during …

DNA methylation changes during mouse spermatogenesis

J del Mazo, G Prantera, M Torres, M Ferraro - Chromosome Research, 1994 - Springer
Genomic imprinting in mammals is thought to be mediated by differences in the methylation
level of cytosine residues in the genome. These differences in DNA methylation are thought …

Inactivation of repeated genes—DNA-DNA interaction?

M Matzke, AJM Matzke, OM Scheid - Homologous recombination and …, 1994 - Springer
Homology-dependent gene silencing, in which the presence of two or more totally or
partially homologous copies of a nuclear gene can lead to inactivation of at least one gene …

Alterations in the methylation status and expression of the raf oncogene in phenobarbital‐induced and spontaneous B6C3F1 mouse liver tumors

JS Ray, ML Harbison, RM McClain… - Molecular …, 1994 - Wiley Online Library
The liver tumor‐prone B6C3F1 mouse (C57BL/6♂× C3H/He♀), in conjunction with the
more susceptible C3H/He paternal strain and the resistant C57BL/6 maternal strain, is an …

CpG island promoter region methylation patterns of the inactive-X-chromosome hypoxanthine phosphoribosyltransferase (Hprt) gene

JG Park, VM Chapman - Molecular and cellular biology, 1994 - Am Soc Microbiol
Inactive-X-chromosome genes in mammalian females have methylated CpG islands. We
have questioned whether there are variable levels of cytosine methylation at different CpG …