Endothelin (ET), a potent endothelium-derived vasoconstrictor peptide [1] contributes to the
regulation of glomerular function both through changes in hemodynamics and through …

Studies were designed to examine the effect of a selective endothelinA (ETA) receptor
antagonist, BQ123, on severe postischemic acute renal failure (ARF) in Sprague-Dawley …

Protective effects of a new endothelin (ET) receptor antagonist, TAK-044, were studied in a
model of acute renal failure (ARF) in rats. ARF was induced by clamping the left renal …

Renal glomeruli isolated from normal rats and from rats with gentamicin-induced renal
failure were incubated with substances that modify nitric oxide (NO) synthesis and the …

Endothelin (ET) is a potent vasoconstrictor that has been implicated in the pathogenesis of
acute renal failure (ARF). In order to investigate the potential role of ET in ARF in the dog …

The effects of platelets on endothelin-1 (ET-1) production were examined by using cultured
bovine pulmonary artery endothelial cells (ECs). Platelets (6 x 10 (6) to 2 x 10 (9) …

Publisher Summary This chapter focuses on the inhibition of the pharmacological effects of
endothelin. Endothelin is one of the most potent vasoconstrictors known and its effects on …

We compared the pressor response to endothelin-1 (ET-1) with that of big endothelin-1 (big
ET-1) in mesenteric arteries, hindquarters and lungs of rats. In these three preparations, both …

Renal glomeruli isolated from Wistar rats were incubated with substances that modify nitric
oxide (NO) synthesis in the presence of the phosphodiesterase inhibitor IBMX and …

Publisher Summary The progress in the prevention and clinical management of shock-
induced acute renal failure (ARF) during the past two decades has been impressive. In the …