Wnt genes and vertebrate development

BA Parr, AP McMahon - Current opinion in genetics & development, 1994 - Elsevier
A variety of experimental approaches have underscored the critical role played by secreted
polypeptide factors, such as those encoded by members of the Wnt gene family, in many …

Formation and inactivation of endogenous cannabinoid anandamide in central neurons

V Di Marzo, A Fontana, H Cadas, S Schinelli, G Cimino… - Nature, 1994 - nature.com
Abstract ANANDAMIDE (N-arachidonoyl-ethanolamine) was recently identified as a brain
arachidonate derivative that binds to and activates cannabinoid receptors1–4, yet the …

The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest

A Graham, P Francis-West, P Brickell, A Lumsden - Nature, 1994 - nature.com
THE pattern of skeletal structures and muscles in the branchial region of the head is
profoundly influenced by the neural crest1, whose cells arise at discrete segmental levels of …

Hoxa-2 expression in normal and transposed rhombomeres: independent regulation in the neural tube and neural crest

V Prince, A Lumsden - Development, 1994 - journals.biologists.com
In this study we have cloned the chick Hoxa-2 gene and analysed its expression during
early development. We find that Hoxa-2 has a rostral limit of expression in the …

Differential and overlapping expression domains of Dlx-2 and Dlx-3 suggest distinct roles for Distal-less homeobox genes in craniofacial development

GW Robinson, KA Mahon - Mechanisms of development, 1994 - Elsevier
During the development of the vertebrate head, cranial neural crest cells migrate into the
branchial arches to form many of the structures of the facial skeleton. These cells follow …

The kreisler mouse: a hindbrain segmentation mutant that lacks tworhombomeres

IJ McKay, I Muchamore, R Krumlauf, M Maden… - …, 1994 - journals.biologists.com
ABSTRACT kreisler is a recessive mutation resulting in gross malformation of the inner ear
of homozygous mice. The defects in the inner ear are related to abnormalities in the …

Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain

N Becker, T Seitanidou, P Murphy, MG Mattéi… - Mechanisms of …, 1994 - Elsevier
Pattern formation in the hindbrain involves a segmentation process leading to the formation
of metameric units, manifested as successive swellings known as rhombomeres (r). In …

Programmed cell death during the earliest stages of spinal cord development in the chick embryo: a possible means of early phenotypic selection

S Homma, H Yaginuma… - Journal of Comparative …, 1994 - Wiley Online Library
The spatiotemporal distribution of cell death in the chick embryo neural tube and spinal cord
(brachial region) was examined between stage (St.) 12 and 22, in plastic semithin sections …

Regulation of the Msx2 homeobox gene during mouse embryogenesis: a transgene with 439 bp of 5′ flanking sequence is expressed exclusively in the apical …

YH Liu, L Ma, LY Wu, W Luo, R Kundu… - Mechanisms of …, 1994 - Elsevier
Msx2, a member of the highly conserved and widely distributed msh homeobox gene family,
is expressed in a variety of sites in the vertebrate embryo, including craniofacial structures …

Rhombomere rotation reveals that multiple mechanisms contribute to the segmental pattern of hindbrain neural crest migration

J Sechrist, T Scherson, M Bronner-Fraser - Development, 1994 - journals.biologists.com
Hindbrain neural crest cells adjacent to rhombomeres 2 (r2), r4 and r6 migrate in a
segmental pattern, toward the first, second and third branchial arches, respectively. Although …