Considerable effort has been made in the last three decades to describe nuclear structural
constituents and define their roles in the functions of the nucleus. Fine-structural analysis …

SMALL nuclear ribonucleoprotein particles (snRNPs) and non-snRNP splicing factors
containing a serine/arginine-rich domain (SR proteins) concentrate in 'speckles' in the …

Acute promyeiocytic leukemia (APL) is associated with at (15; 17) transiocation that creates
the promyelocyte-retinoic acid receptor a (PML-RARa) fusion gene. immunohistochemistry …

The influenza virus RNA segment 8 encodes two proteins, NS1 and NS2, by differential
splicing. The collinear transcript acts as mRNA for NS1 protein, while the spliced mRNA …

Acute promyelocytic leukemia (APL) is characterized by a specific t (l5; 17) translocation that
fuses the retinoic acid receptor a (RAFta) to a novel gene product, PML. The involvement of …

In human myxoid liposarcoma, a chromosomal rearrangement leads to fusion of the growth-
arresting and DNA-damage-inducible transcription factor CHOP (GADD153) to a peptide …

We report the identification and molecular characterization of a novel nucleolar protein of rat
liver. As shown by coimmunoprecipitation this protein is associated with a previously …

We have studied the distribution of poly (A)+ RNA in the mammalian cell nucleus and its
transport through nuclear pores by fluorescence and electron microscopic in situ …

Epstein-Barr virus (EBV), an oncogenic herpesvirus, encodes two small RNAs (EBERs) that
are expressed at high levels during latent transformation of human B lymphocytes. Here we …

We have examined the functional significance of the organization of pre-mRNA splicing
factors in a speckled distribution in the mammalian cell nucleus. Upon microinjection into …