Methodological research in biostatistics has been dominated over the last twenty years by
further development of Cox's regression model for life tables and of Nelder and …

In the epidemiologic literature, tracking is used to describe the longitudinal development of a
certain variable. There is available no single definition of tracking, but the following concepts …

Since our first edition of this book, many developments in statistical mod elling based on
generalized linear models have been published, and our primary aim is to bring the book up …

This text bridges the gap between sound theoretcial developments and practical, fruitful
methodology by providing solid justification for standard symptotic statistical methods. It …

A random-effects ordinal regression model is proposed for analysis of clustered or
longitudinal ordinal response data. This model is developed for both the probit and logistic …

There are approximately 20 000 excess deaths from cardiovascular disease each winter in
England and Wales. The reasons for the excess have not been fully elucidated. For one …

Suppose the expected value of a response variable Y may be written h (X β+ γ (T)) where X
and T are covariates, each of which may be vector-valued, β is an unknown parameter …

How an atherosclerotic plaque evolves from minimal diffuse intimal hyperplasia to a critical
lesion is not well understood. Cellular proliferation is a relatively infrequent and modest …

Regression models containing fixed and random effects may have a response variable
which is not normally distributed. The generalized mixed model includes both discrete and …

The modelling of correlated binary outcomes, in such a way that the marginal response
probabilities are still logistic, is considered. Different association measures for the …