Preclinical models of behavioral and toxic effects of cocaine are reviewed and their potential
for predicting compounds with efficacy and safety in the medical management of cocaine …

Twelve rats were trained to press one lever after cocaine injection (3 mg/kg ip) and another
lever after saline injection. Once rats were rdiab, discriminating cocaine from saline, other …

Previous studies have shown that the dopamine (DA) reuptake inhibitor 1-(2-[bis (4-
fluorophenyl)-[methoxy] ethyl)-4-(3-phenylpropyl) piperazine (GBR12909) antagonizes the …

The highly abused psychostimulant cocaine elicits psychological manifestations in humans
(eg, mood elevation, euphoria) that have been well described and are similar to those of the …

1. 10 male cocaine dependent patients and 10 sex matched controls were administered
several behavioral measures of aggression including the Buss-Durkee Hostility Inventory …

The present study examined the ability of cocaine to produce behavioral and
neuropharmacological effects through serotonin (5-HT) systems. Pretreatment with …

Binding to the dopamine transporter and inhibiting dopamine reuptake are considered
important factors in regulating behavioral effects of cocaine. One prominent behavioral effect …

The ability of D 1 and D 2 dopamine antagonists to reduce the subjective effects of nicotine
was examined in rats trained to discriminate nicotine (0.3 mg/kg, base) from saline. Each of …

Abstract Ritanserin, a 5-HT 2 1 c antagonist, has been suggested to reduce the preference
for cocaine in rats. In the present experiment, the action of ritanserin was investigated in …

The influence of cocaine on cytokine release by mouse peritoneal macrophages has been
investigated in vitro. LPS-stimulated TNF and IL-1 secretion were suppressed by cocaine in …