THYROID follicular cell tumors present a unique model for the study of genetic and
environmental factors predisposing to benign nodule formation, well differentiated malignant …

Much progress has been made in our understanding of the epidemiologic factors, biologic
behavior, diagnosis, treatment, and molecular biology of well-differentiated thyroid …

A newly cloned gene named wild-type p53-activated fragment 1 (WAF1; also known as p21,
Pic-1, Cip-1, or SDI1) is directly regulated by p53 and can itself suppress tumor cell growth …

Abstract TTF-1 and PAX-8 are tissue-specific transcription factors expressed in the thyroid
follicular cells, contributing to the maintenance of the differentiated phenotype. In fact, it has …

Background. The establishment of cell lines from thyroid carcinomas can provide an in vitro
model of oncogenesis. B‐CPAP is a new cell line that has been obtained from a …

Cells with divergent mutant alleles of the p53 gene have different biological and biochemical
properties in vitro. Increasing evidence indicates that p53 is a transcriptional activator, and …

Abstract purpose: Thyroid nodules are very common, yet the vast majority are biologically
benign. The extreme difficulty facing the clinician selecting potentially malignant thyroid …

In an attempt to find whether or not p53 immunoreactivity in the thyroid gland is restricted to
undifferentiated carcinomas and to evaluate the putative prognostic usefulness of its …

Cancers are thought to develop as a result of sequential mutations of genes important in the
control of cellular growth. Recently investigators identified a number of genetic defects that …

AIM--To study the expression of p53 tumour suppressor gene in anaplastic carcinomas
arising from thyroid papillary carcinomas. METHODS--Formalin fixed, paraffin wax …