[HTML][HTML] Aciclovir: a reappraisal of its antiviral activity, pharmacokinetic properties and therapeutic efficacy

AJ Wagstaff, D Faulds, KL Goa - Drugs, 1994 - Springer
Aciclovir (acyclovir) is a nucleoside analogue with antiviral activity in vitro against the herpes
simplex viruses (HSV), varicella zoster virus (VZV), Epstein-Barr virus (EBV) …

Recent advances in the management of AIDS-related opportunistic infections

HC Lane, BE Laughon, J Falloon… - Annals of internal …, 1994 - acpjournals.org
Secondary infections remain the leading cause of death in patients with the acquired
immunodeficiency syndrome (AIDS). Dealing with the rapidly evolving spectrum of infectious …

BK and JC viruses in human immunodeficiency virus type 1-infected persons: prevalence, excretion, viremia, and viral regulatory regions

A Sundsfjord, T Flaegstad, R Flø… - Journal of Infectious …, 1994 - academic.oup.com
Human polyomavirus BK (BKV) and JC (JCV) infections were examined in persons infected
with human immunodeficiency virus type I (HIV-1). High frequencies of BKV (24%) and JCV …

Effects of high-dose oral acyclovir on herpesvirus disease and survival in patients with advanced HIV disease: a double-blind, placebo-controlled study

MS Youle, BG Gazzard, MA Johnson, DA Cooper… - Aids, 1994 - journals.lww.com
Objective: To determine the efficacy of high-dose oral acyclovir in preventing
cytomegalovirus (CMV) and other herpesvirus disease in patients with advanced HIV …

Persistent cytomegalovirus infection of semen increases risk of AIDS

R Detels, CT Leach, K Hennessey, Z Lin… - Journal of Infectious …, 1994 - academic.oup.com
To evaluate if persistent cytomegalovirus (CMV) infection of semen in human
immunodeficiency virus type 1 (HIV-1) antibody-positive men increases AIDS risk, serial …

Alcoholism and rapid progression to AIDS after seroconversion

IW Fong, S Read, MA Wainberg… - Clinical Infectious …, 1994 - academic.oup.com
Rapid progression of infection with human immunodeficiency virus type 1 (HIV-1) to AIDS
after seroconversion is rare; it has been associated with coinfection by cytomegalovirus or …

The magnitude of HIV replication in monocytes and macrophages is influenced by environmental conditions, viral strain, and host cells

J Chang, S Li, H Naif… - Journal of Leucocyte …, 1994 - academic.oup.com
It has been difficult to standardize the effects of various stimuli on HIV replication in
monocytes and macrophages in different laboratories. In this study we have shown that it is …

Heterosexual spread of HIV infection

P Stratton, NJ Alexander - Reproductive Medicine Review, 1994 - cambridge.org
Sexual transmission is the most common route of spread of human immunodeficiency virus
(HIV), with heterosexual transmission of HIV infection accounting for 90% of those infected in …

High versus ultra-high purity factor VIII concentrate therapy: prospective evaluation of immunological and clinical parameters in HIV seronegative and seropositive …

D Varon, S Schulman, R Dardik… - Thrombosis and …, 1994 - thieme-connect.com
This study aimed at evaluation of the immunological status and the clinical course of both
HIV seronegative and seropositive hemophiliacs treated with either an ultra-pure factor VIII …

Cytomegalovirus as a co-factor of disease progression in human immunodeficiency virus type 1 infection

S Nardiello, L Digilio, T Pizzella, B Galanti - International Journal of …, 1994 - Springer
Cytomegalovirus has been suggested as a co-factor of disease progression in patients with
human immunodeficiency virus type 1 infection. Cytomegalovirus infection is highly …