The integrity of the blood-brain barrier may play an important pathophysiological role during
postischemic reperfusion. To determine the factors that lead to exacerbation of brain injury …

Mild to moderate hypothermia (30–33° C) reduces brain injury after brief (< 2-h) periods of
focal ischemia, but its effectiveness in prolonged temporary ischemia is not fully understood …

We studied the role and relationship of the putative mediators of coupling of cerebral blood
flow (CBF) and neuronal activation, adenosine (Ado) and nitric oxide (NO). Topical brain …

We examined the relationship between spontaneous changes in regional cerebral blood
flow and electrocortical (ECoG) activity in spinalized rats anesthetized with 1.5% isoflurane …

The endothelium-derived relaxing factor, probably nitric oxide (NO), is a potent vasodilator
that regulates the vascular tone in several vascular beds, including the brain. We explored …

We tested the abilities of two potent non-N-methyl-d-aspartate (non-NMDA) glutamate
antagonists [2, 3-dihydroxy-6-nitro-7-sulfamoylbenzo (F) quinoxaline (NBQX)] and [1-(4 …

BW619C89 [4-amino-2-(4-methyl-1-piperazinyl)-5-(2, 3, 5-trichlorophenyl) pyrimidine is a
use-dependent blocker of voltage-dependent sodium channels that blocks veratrine …

✓ Deep to moderate hypothermia (24° to 30° C) during focal cerebral ischemia reduces
infarct volume but must be initiated before the onset of ischemia to be effective and has …

SNX-111 (NEUREX Corporation, Menlo Park, CA, USA) an ω-conopeptide, was tested for
cytoprotection following normothermic ischemia using both a four-vessel occlusion model of …

Oxidative damage by free radicals has been proposed as a mechanism of cerebral injury
due to ischemia and reperfusion. Hypothermia protects against ischemic necrosis; however …