Asthma is a chronic obstructive disease of the lower airways. It is characterized by episodic
exacerbations of at least partially reversible airflow limitation, along with bronchial …

Occupational asthma is characterized by variable airflow obstruction occurring in the
workplace. The presence of airways inflammation and hyperreactivity provides further …

The German reunification offers a unique opportunity to study the impact of environmental
factors on the development of childhood respiratory and allergic disorders in ethnically …

Sib-pair analysis of 170 individuals from 11 Amish families revealed evidence for linkage of
five markers in chromosome 5q31. 1 with a gene controlling total serum immunoglobulin E …

To investigate the role of IL‐4 in vivo in allergic asthma, we developed a murine model of
allergen‐induced airway inflammation. Repealed daily exposures of actively immunised …

Genetics studies of total serum IgE levels were performed since high IgE levels correlate
with clinical expression of allergy and asthma. Families ascertained through a parent with …

Recent in vitro investigations have demonstrated that corticosteroids in combination with
interleukin-4 induce the synthesis of IgE. Corticosteroids are increasingly being used to treat …

The factors that determine the occurrence of airway hyperreactivity in the general population
are not clearly understood. This study was designed to assess the independent effects of …

Current research in the fieM of atopy is directed abnost exclusively tou, ards treatment of
established allergic disease. In particular, treatment has conce,, n~ ted on controlling the …

Background Asthma mortality among young people varies widely between different
countries. Geographical differences in asthma prevalence are also believed to exist, but …