Risk factors for encephalopathy and mortality during melarsoprol treatment of Trypanosoma brucei gambiense sleeping sickness
J Pepin, F Milord, AN Khonde… - Transactions of the …, 1995 - academic.oup.com
This paper reviews the incidence of, and risk factors for, drug-induced encephalopathy and
mortality (from all causes) during treatment with melarsoprol of 1083 patients with …
mortality (from all causes) during treatment with melarsoprol of 1083 patients with …
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase: gene isolation and expression and characterization of the enzyme
F Gamarro, PL Yu, J Zhao, U Edman, PJ Greene… - Molecular and …, 1995 - Elsevier
The gene encoding the bifunctional dihydrofolate reductase (DHFR) and thymidylate
synthase (TS) of Trypanosoma brucei brucei has been isolated and expressed in …
synthase (TS) of Trypanosoma brucei brucei has been isolated and expressed in …
Novel polyamine derivatives as potent competitive inhibitors of Trypanosoma cruzi trypanothione reductase
MC O'Sullivan, Q Zhou - Bioorganic & Medicinal Chemistry Letters, 1995 - Elsevier
The inhibiting effects of several spermidine and spermine derivatives on T. cruzi
trypanothione reductase were assessed. Spermidine and spermine derivatives containing …
trypanothione reductase were assessed. Spermidine and spermine derivatives containing …
Successful treatment of experimental murine Trypanosoma brucei infection with topical melarsoprol gel
JM Atouguia, FW Jennings, M Murray - Transactions of the Royal Society of …, 1995 - Elsevier
Melarsoprol gel applied topically (0· 1 mL for at least 2 d) can cure late-stage Trypanosoma
brucei brucei and T. b. rhodesiense infections in mice. The best regimen was 3 applications …
brucei brucei and T. b. rhodesiense infections in mice. The best regimen was 3 applications …